literature

SARS_CoV_2 mutation literature information.

RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant.

PMID: 35293849 2022 Emerging microbes & infections

Method: The negative control used the same amount of DEPC water instead of nucleic a

Figure: (E) The specific differences in the R203M, R203K/G204R and T205I mutations in the N gene sequence.

Figure: Numbers 1-4: the amplified curve of the R203M, R203K/G204R, T205I mutant-containing template and wild template using the conserved primer set.

An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.

PMID: 34272947 2022 Clinical infectious diseases

Result: Amino acid changes in hospitalized patients compared with all patients with >=10% prevalence and a 5% change between the 2 groups showed that 4 mutations (S: P681H, NSP6: 106-108del, N: S194L, and N: T205I) were present to a higher degree, but not significantly higher or didn't reach statistical significance.

Discussion: It was also the only lineage with the occasional co-occurrence of N:T205I and N:S194L, which were both seen in higher percentages of sequences from known hospitalized patients.

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.

PMID: 34671771 2022 bioRxiv

Introduction: Three prominent mutations occur in this region including R203K/G204R, a double substitution (KR mt) present in the alpha and gamma variants; T205I present in the beta variant; and R203M that occurs in the kappa and delta variants.

Result: The second prominent mutation, T205I, is present in the beta, eta, and mu lineages.

Result: While also emerging early in the pandemic, T205I is a minority variant which peaked at 9% in February 2021.

Reduced levels of convalescent neutralizing antibodies against SARS-CoV-2 B.1+L249S+E484K lineage.

PMID: 34780883 2022 Virus research

Table: T205I

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Table: T205I

Discussion: Of note, the dataset on May 2021, we found a haplotype 2B_5 contained three mutations in nsp3 (S126L, T350I, P822L), one mutation in nsp6 (L75F), one mutation in nsp13 (S259L), three mutations in spike protein (N439K, P681R, G1251V), and one mutation in N (T205I).

Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.

PMID: 34968862 2022 Computers in biology and medicine

Table: T205I

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Table: T205I

In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape.

PMID: 35149224 2022 Infection, genetics and evolution

Result: In contrast, nsSNVs T205I and Y144del showed lower antigenicity scores.

Table: T205I

Discussion: D3L, P80R, S235F, and T205I, generated more potential epitopes in comparison to the REF peptides.

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: Other than the S protein, the majority of beta (B.1.351) genomes had amino acid changes within ORF1a (T265I, K1655N, K3353R), ORF1b (P214L), ORF3a (Q57H, S171L), E (P71L), and N (T205I).

Insights on the SARS-CoV-2 genome variability: the lesson learned in Brazil and its impacts on the future of pandemics.

PMID: 34730486 2021 Microbial genomics

Discussion: Moreover, the variants of concern B.1.351, B.1.427, and B.1.429 feature the T205I substitution, which were identified in 0.69% of our sequences from May to September (Table S1).

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