literature

SARS_CoV_2 mutation literature information.

Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.

PMID: 34968862 2022 Computers in biology and medicine

Result: Among substitution, two in nsp1 (Q63L, G82S), seven in nsp2 (R197C, K261 N, F275L, K292E, V378I, D448 N, V627F) and one deletion at N449, Nine amino acids substitutions in nsp3 (L1174I, T1246I, K1308 N, T1754I, T2016K, T2408F, L2564F, A2619V, Q2702H), two substitutions (

Worldwide SARS-CoV-2 haplotype distribution in early pandemic.

PMID: 35171928 2022 PloS one

Table: p.Thr2016Lys

SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.

PMID: 35386683 2022 Frontiers in cellular and infection microbiology

Result: Notably, all the mutations associated with the recovered group (S2015R, Y789Y, T2016K, S194*, A4489V) showed a frequency flip, whereas two mutations associated with the mortality group showed a shift in their frequency from our cohort to global level.

Discussion: Moreover, a significant frequency flip (p-value = 0.0001) was seen for the five mutations, S2015R, Y789Y, T2016K, S194*, and A4489V, in the recovered with a low global presence, indicating that the mutations associated with COVID-19 recovery are deselected by the virus during its evolution.

Clinical and whole genome characterization of SARS-CoV-2 in India.

PMID: 33529260 2021 PloS one

Result: One synonymous (23929C>T in the S gene) and four nonsynonymous mutations (

Result: One synonymous (23929C>T in the S gene) and four nonsynonymous mutations (6312 C>T{T2016K}, 11083G>T{L3606F}, 13730C>T{A4489V} in ORF1ab; 28311C>T{P13L} in the N gene) were observed in the sample (GMCRR1191/2020) collected from patient with cluster infection and no travel history, and who succumbed to the disease.

Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan.

PMID: 33544733 2021 PloS one

Result: Four amino acid substitutions were found in Asian strain O: three (218: Arginine to Glycine, 2016: Threonine to Lysine, 3606: Leucine to Phenylalanine) were in ORF1a and one (13: Proline to Leucine) was in N.

A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.

PMID: 33705994 2021 Computers in biology and medicine

Table: T2016K

An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.

PMID: 34067745 2021 Viruses

Result: It was noted that 331/406 sequences had a conserved pattern in the ORF1ab (T2016K, A4489V) and N: P13L, Figure 3 (blue and its shades).

Emergence and expansion of highly infectious spike protein D614G mutant SARS-CoV-2 in central India.

PMID: 34518554 2021 Scientific reports

Result: Important non-synonymous variants includes RdRp: A97V observed in 7 strains including virus introductory index cases from three different districts, N: P13L observed in 4 strains, NSP3: T2016K observed in 7 strains including introductory index cases from three different districts.

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Result: Mutational analysis of the 7213 SARS-CoV-2 genome sequences revealed the following high rate recurrent mutations in the ORF1ab polyprotein sequence: T265I and D448del (nsp2 coding region), T2016K (nsp3), G3278S (nsp5), L3606F (nsp6), A4489V and P4715L (RNA dependent RNA polymerase), and P5828L, Y5865C (RNA helicase region).

Result: The following mutations: N p

Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and Transmission.

PMID: 34733263 2021 Frontiers in microbiology

Table: T2016K

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