SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performance.
PMID: 34758391
2022
International journal of infectious diseases
Abstract: The T135I mutation was also identified in one variant case in which the rapid antigen test and RT-PCR test were discordantly negative and positive, respectively.
Abstract: These findings suggest that the variants undetected by the Panbio COVID-19 rapid antigen test may be due to the T135I mutation in the N protein, posing a potential diagnostic risk for commercially available antigen tests.
Result: Another novel amino acid substitution was observed in the T135I mutation in Case 5 (Figure 1 ).
Table: T135I
Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617.
Result: Additionally, six of these 22 sites were led by C-to-U transition (R134N in nsp10, A394V in nsp14, A222V and H1101D/Y in S, and P13T and T135I in N).
Table: T135I
Impact of Early Pandemic Stage Mutations on Molecular Dynamics of SARS-CoV-2 M(pro).
PMID: 32853525
2020
Journal of chemical information and modeling
Result: Another cluster of mutations is distributed in domain II and includes 3 subgroups: a group of fully immobilized positions (A116V, A129V, P132L, T135I, and I136V), a group of bridging (hinge-like) sites that connect rigid and flexible regions (Y101C, R105H, P108S, N151D, V157I/L, C160S, A173V, and P184L/S), and a group of mostly mobile residues (T190I, A191V, and A193V) (Figure 18, panel B).
SARS_CoV_2 mutation literature information.
PMID: 
2022
International journal of infectious diseases
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