Figure: The B.1.1.389 was the only lineage that carries the S:T1117I as a characteristic mutation (marker for the lineage), unlike the other groups in which this mutation is not widely found among the genomes of the lineage.
Figure: The drug was docked into the HR1 region of S2 domain in the spike, using the WT or the mutated (S:D614G and S:T1117I) proteins.
Figure: The lineage is characterized by the presence of eight mutations including two in the spike, the D614G and the
Discussion: We started by comparing all the available sequences with the S:T1117I around the world.
Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica.
PMID: 33905892
2021
Infection, genetics and evolution
Conclusion: Interestingly, the variant T1117I in the Spike has increased its frequency along time from March to November 2020.
Conclusion: The Spike variant T1117I must be closely surveyed to see if it will become the predominant circulating variant in our country.
Result: The T1117I and D614G are located in different domains.
Table: T1117I
Table: p.Thr1117Ile
Figure: Frequency of
Discussion: According to GISAID (December 31st, 2020), T1117I occurred merely 213 times worldwide (0.08% of all samples with Spike sequence in the database) in only 19 countries, including Colombia and New Zealand.
E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.
PMID: 34044192
2021
Infection, genetics and evolution
Introduction: Without previous introductions in other Latin American countries, which have been affected by their own specific mutations, such as the convergent evolution of the S:T1117I in Costa Rica the E484K mutation arose independently in Brazil and was identified in the Rio de Janeiro state (Southeast Brazil) in early-October carried by the P.2 lineage.
Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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