literature

SARS_CoV_2 mutation literature information.

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

PMID: 34599175 2021 Nature communications

Result: In contrast, T1027I and D1118H are both buried in the trimerisation interface of the S2 subunit.

Result: Synonymous mutations at site 15324 and S:T1027I appear to be some of the earliest mutations that occurred in the evolution of lineage B.1.620, both of which are found in at least one other lineage associated with Cameroon (B.1.619), followed by S:E484K which also appears in genomes closest to lineage B.1.620.

Result: The remaining mutations in the spike protein:P681H, T1027I and D1118H:are uncharacterised to the best of our knowledge.

Epidemiology of COVID-19: An updated review.

PMID: 34759999 2021 Journal of research in medical sciences

Table: T1027I

Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation.

PMID: 34763050 2021 Infection, genetics and evolution

Result: The Gamma sequences generated herein presented the classical mutational signatures in spike glycoprotein L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F, with some exceptions, as in the sample hCoV-19/Brazil/LMM53965 and hCoV-19/Brazil/LMM54004 that change a guanine for an adenine in 614 position (D614G D614A) and the hCoV-19/Brazil/LMM54029 that change a histidine for a glutamic acid in 655

Organ-specific genome diversity of replication-competent SARS-CoV-2.

PMID: 34785663 2021 Nature communications

Abstract: In parallel, we identify organ-specific SARS-CoV-2 genome diversity and mutations of concern N501Y, T1027I, and Y453F, while the patient had died long before reported emergence of VOCs.

Result: Similar to the N501Y mutation, we identified the C24642T (T1027I amino acid substitution) mutation in S, present in current strains of the Gamma GH/501Y.V3 [P1] lineage, at peaking concentrations of 50% in lungs and plasma, as well as in their viral offspring in Vero E6 cells.

Table: T1027I

Re-emergence of Gamma-like-II and emergence of Gamma-S:E661D SARS-CoV-2 lineages in the south of Brazil after the 2021 outbreak.

PMID: 34789293 2021 Virology journal

Table: T1027I

SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.

PMID: 34796036 2021 Immune network

Introduction: Like SARS-CoV-2 beta variant, most mutation sites locate in S1 region of S gene except a single mutation site T1027I in Central helix domain of S2 region.

Table: T1027I

Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.

PMID: 34805715 2021 ACS omega

Introduction: For example, the P.1 lineage detected first in Brazil is characterized by several amino acid (AA) substitutions mostly located either in RBD or in NTD: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I, which are shown to reduce neutralization by some antibodies.

Table: T1027I

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.

PMID: 34925381 2021 Frontiers in immunology

Introduction: The Gamma P.1 variant encodes an S protein with 12 mutations (L18F, T20N, P26S, D138Y, R190S, K417N/T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F), two of which are in the RBD (E484K, and N501Y).

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

PMID: 35095827 2021 Frontiers in microbiology

Table: p.Thr1027Ile

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: T1027I