Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.
Introduction: In the spike protein of the B.1.1.28 strain, there are eleven mutations, including L18F, T20N, P26S, D138Y, R190S, H655Y, T1027I, D614G, K417T, E484K, and N501Y.
Table: T1027I
Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.
PMID: 34896696
2022
Journal of infection and public health
Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,
Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.
PMID: 34848355
2022
Infection, genetics and evolution
Table: T1027I
Antigenicity comparison of SARS-CoV-2 Omicron sublineages with other variants contained multiple mutations in RBD.
Result: In contrast, T1027I and D1118H are both buried in the trimerisation interface of the S2 subunit.
Result: Synonymous mutations at site 15324 and S:T1027I appear to be some of the earliest mutations that occurred in the evolution of lineage B.1.620, both of which are found in at least one other lineage associated with Cameroon (B.1.619), followed by S:E484K which also appears in genomes closest to lineage B.1.620.
Result: The remaining mutations in the spike protein:P681H, T1027I and D1118H:are uncharacterised to the best of our knowledge.
Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Vaccine
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