Introduction: The slight decrease in the neutralizing activity was linked to the S982A mutation located in the S2 domain of the Spike protein.
A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic.
Abstract: Genetic analysis of whole SARS-CoV-2 genomic sequences of the aforementioned lineages revealed the presence of mutations within the S protein (L18F, DeltaH69/V70, S898F, DeltaY144, S162G, A222V, N439K, N501Y, A570D, D614G, P681H, S982A and D1118H) that confer higher transmissibility and/or antibody escape (immune evasion) upon the virus.
Introduction: Furthermore, mutations/deletions in the S-protein, such as L18F, DeltaH69/V70,
Introduction: VOC, 202012/01) with multiple S protein mutations (deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) spread rapidly across South East England and London.
The Antigenicity of Epidemic SARS-CoV-2 Variants in the United Kingdom.
Introduction: Since December 2020, the VOC-202012/01 (VOC-202012/01 variant, including multiple mutations 69-70del, 144/145del, N501Y, A570D, P681H, T716I, S982A, and D1118H) has been increasing rapidly.
Method: The spike protein was modeled based on the Protein Data Bank coordinate set 6VXX, showing the mutation N501Y in S1 and S982A in S2.
Result: Structure modeling of the mutation N501Y in S1 and S982A in S2 was showed asFigure 2B .
Discussion: Our results therefore indicate that the N501Y, P681H, and PMID: 34224110
2021
Virologica Sinica
Result: Mutations in B.1.1.7 (including 69-70del, Y144del, N501Y, A570D, T716I, S982A, D1118H, and D614G) had a mutation frequency of around 5%.
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Discussion: The set of signature variants includes 8 changes from S protein: deletion 69-70, deletion 144-145, N501Y (A23063T), A570D (C23271A), D614G, P681H (C23604A), T716I (C23709T), S982A (T24506G), D1118H (G24914C).
Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.
Discussion: Moreover, this mutation is also a characteristic of the newly emerged SARS-CoV-2 variants, which are defined by multiple mutations in the S glycoprotein (Delta69-70, Delta144, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H).
Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines.
Method: The B.1.1.7 Spike we used carries the mutations found in GISAID Accession Number EPI_ISL 668152: del 69-70, del145, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.
Structural modelling of SARS-CoV-2 alpha variant (B.1.1.7) suggests enhanced furin binding and infectivity.
Introduction: The B.1.1.7 SARS-CoV-2 variant strain exhibits missense mutations (N501Y, A570D, P681H, D614G, T716I, S982A, D1118H) and three deletions in residues H69, V70, Y144.
Result: Genome sequencing of the new B.1.1.7 SARS-CoV-2 strain presented missense mutations (N501Y, A570D, P681H, D614G, T716I, S982A, D1118H) and three deletions in residues H69, V70, Y144.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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