literature

SARS_CoV_2 mutation literature information.

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.

PMID: 34351895 2021 PLoS computational biology

Result: Namely, B.1.1.7 contains N501Y, A570D, D614G, P681H, T716I, S982A, D1118H and deletions on positions 69, 70 and 144.

Molecular Evolution and Epidemiological Characteristics of SARS COV-2 in (Northwestern) Poland.

PMID: 34372500 2021 Viruses

Result: Additionally, for the T716I and S982A variants, substitution frequencies increased over time (respectively, from 0.88% in December to 51.61% in February (OR: 10.59, 95% CI: 7.13-16.11, p < 0.0001) and from 0.88% in December to 50.97% in February (OR: 10.53, 95% CI: 6.97-15.72, p < 0.0001).

Result: Co-existence of DeltaH69V70, DeltaY144, P681H, T716I, S982A, A570D, N501Y, and D1118H was the signature for the B.1.1.7 (20H/501Y.V1) variant.

Discussion: Our analysis shows that subsequently, three genetic lines of the SARS-CoV-2 molecular evolution have emerged, with the largest clade (Clade 1, lineages B.1.1.*) being the most diverse genetically, with a signif

The Emergence and Spread of Novel SARS-CoV-2 Variants.

PMID: 34409009 2021 Frontiers in public health

Table: S982A

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: B.1.1.7: H69 deletion, V70 deletion, Y144deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.

Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.

PMID: 34442775 2021 Microorganisms

Abstract: However, the key mutations-N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) were also recorded in spike protein.

Result: The most common amino acid substitutions were D614G (83.4%) followed by N501Y (44.6%), S982A (44.4%), A570D (43.3%), T716I (40.4%), and P681H (40.1%) in Spike (S) protein.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: According to the % frequencies of the genetic markers A570D (23271C>A), D614G (23403A>G), P681H (23604C>A), T716I (23709C>T), S982A (24506T>G), and D1118H (24914GG>C), the Beta.1.1.7/alpha lineage VOC was detected in 80.6% +- 8.3 (mean +- SE), (median of 80.8%) of the total sequencing reads.

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany.

PMID: 34452356 2021 Viruses

Result: Intriguingly, one of the genomes (EPI_ISL_1567985) encoded S-L452R, S-N501Y, and S-G1219V associated with six other amino acid changes in the spike (A570D, D614G, P681H, T716I, S982A, I1221V), most interestingly comprising D614G and also P681H (Figure 4B).

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: S982A

Phylogenicity of B.1.1.7 surface glycoprotein, novel distance function and first report of V90T missense mutation in SARS-CoV-2 surface glycoprotein.

PMID: 34466389 2021 Meta gene

Method: 3 to B.1.1.7 spike protein defining mutations - defining deletions:H69,V70,Y144/ Y145 plus defining amino acid substitutions: N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, two types of events can be observed in 21 out of 24 variants: .

Method: 3 to B.1.1.7 spike protein defining mutations - defining deletions:H69,V70,Y144/ Y145 plus defining amino a

Discussion: On the other hand, given that V10 emerged from V7, then S982A deletion must had occurred in V7.

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