Abstract: Genetic analysis of whole SARS-CoV-2 genomic sequences of the aforementioned lineages revealed the presence of mutations within the S protein (L18F, DeltaH69/V70, S898F, DeltaY144, S162G, A222V, N439K, N501Y, A570D, D614G, P681H, S982A and D1118H) that confer higher transmissibility and/or antibody escape (immune evasion) upon the virus.

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Introduction: Furthermore, mutations/deletions in the S-protein, such as L18F, DeltaH69/V70,

 PMID: 34217923       2021       Virology

Introduction: VOC, 202012/01) with multiple S protein mutations (deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) spread rapidly across South East England and London.

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4  The Antigenicity of Epidemic SARS-CoV-2 Variants in the United Kingdom.

 PMID: 34220844       2021       Frontiers in immunology

Introduction: Since December 2020, the VOC-202012/01 (VOC-202012/01 variant, including multiple mutations 69-70del, 144/145del, N501Y, A570D, P681H, T716I, S982A, and D1118H) has been increasing rapidly.

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Method: The spike protein was modeled based on the Protein Data Bank coordinate set 6VXX, showing the mutation N501Y in S1 and S982A in S2.

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Result: Structure modeling of the mutation N501Y in S1 and S982A in S2 was showed asFigure 2B .

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Discussion: Eight of the 17 mutations in the VOC-202012/01 variant are located in the spike protein, including 69-70del,

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5  Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants.

 PMID: 34224110       2021       Virologica Sinica

Result: Mutations in B.1.1.7 (including 69-70del, Y144del, N501Y, A570D, T716I, S982A, D1118H, and D614G) had a mutation frequency of around 5%.

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6  Updated SARS-CoV-2 single nucleotide variants and mortality association.

 PMID: 34245452       2021       Journal of medical virology

Discussion: The set of signature variants includes 8 changes from S protein: deletion 69-70, deletion 144-145, N501Y (A23063T), A570D (C23271A), D614G, P681H (C23604A), T716I (C23709T), S982A (T24506G), D1118H (G24914C).

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7  Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.

 PMID: 34258664       2021       Archives of virology

Discussion: Moreover, this mutation is also a characteristic of the newly emerged SARS-CoV-2 variants, which are defined by multiple mutations in the S glycoprotein (Delta69-70, Delta144, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H).

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8  Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines.

 PMID: 34264104       2021       Microbiology resource announcements

Table: S982A

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9  Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.

 PMID: 34312390       2021       Nature communications

Method: The B.1.1.7 Spike we used carries the mutations found in GISAID Accession Number EPI_ISL 668152: del 69-70, del145, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.

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10  Structural modelling of SARS-CoV-2 alpha variant (B.1.1.7) suggests enhanced furin binding and infectivity.

 PMID: 34314772       2021       Virus research

Introduction: The B.1.1.7 SARS-CoV-2 variant strain exhibits missense mutations (N501Y, A570D, P681H, D614G, T716I, S982A, D1118H) and three deletions in residues H69, V70, Y144.

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Result: Genome sequencing of the new B.1.1.7 SARS-CoV-2 strain presented missense mutations (N501Y, A570D, P681H, D614G, T716I, S982A, D1118H) and three deletions in residues H69, V70, Y144.

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