literature

SARS_CoV_2 mutation literature information.

Design of SARS-CoV-2 Variant-Specific PCR Assays Considering Regional and Temporal Characteristics.

PMID: 35285246 2022 Applied and environmental microbiology

Result: As a result, for the Alpha variant, we identified nine mutations in the spike gene: S:Delta69/70, S:Delta144, S:N510Y, S:A570D, S:D614G, S:P681H, S:T716I, S:S982A

Result: For the Alpha variant, we found three acceptable mutations, S:A570D, S:T716I, and S:S982A.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Table: S982A

Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds.

PMID: 35330908 2022 Frontiers in immunology

Table: S982A

A SARS-CoV-2 Wuhan spike virosome vaccine induces superior neutralization breadth compared to one using the Beta spike.

PMID: 35273217 2022 Scientific reports

Method: Pre-fusion spike protein ectodomain DNA constructs were designed containing the following mutations compared to the Wuhan variant (Wuhan Hu-1; GenBank: MN908947.3): deletion of H69, V70 and Y144, N501Y, A570D, D614G, P681H, T716I, S982A and D1118H in Alpha; L18F, D80A, D215G, L242H, R246I, K417N, E484K, N501Y, D614G and A701V in Beta;

E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces.

PMID: 35341044 2022 PeerJ

Introduction: The Alpha variant fastly spread across dozens of countries and carried 17 mutations, including eight in the spike protein (HV 69-70 deletion, Y144 deletion, N501Y, A570D, P681H, T761I, S982A, and D1118H), which are the basis of three COVID-19 vaccines licensed.

A screening strategy for identifying the dominant variant of SARS-COV-2 in the fifth peak of Kurdistan- Iran population using HRM and Probe-based RT-PCR assay.

PMID: 35271889 2022 Journal of virological methods

Table: S982A

Interaction Analysis of the Spike Protein of Delta and Omicron Variants of SARS-CoV-2 with hACE2 and Eight Monoclonal Antibodies Using the Fragment Molecular Orbital Method.

PMID: 35312321 2022 Journal of chemical information and modeling

Introduction: The S protein mutations in the alpha variant are DeltaH69/DeltaV70, Delta144/144, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.

Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.

PMID: 35101265 2022 Vaccine

Table: S982A

Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein Stability.

PMID: 35163572 2022 International journal of molecular sciences

Introduction: S-B.1.1.7 variant of the SARS-CoV-2 has 9 of the 17 mutations (Delta69-70 deletion, Delta144 deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) in the S protein, featuring N501Y mutation, which can increase binding affinity with ACE2 while eliciting immune escape from RBD-targeting antibodies.

Method: A systematic mutational scanning and sensitivity analysis of the functional RBD residues (K417, E484, N501), S-B.1.1.7 mutational sites (N501Y, A570D, P681H,

Rapid detection of multiple SARS-CoV-2 variants of concern by PAM-targeting mutations.

PMID: 35156077 2022 Cell reports methods

Abstract: Here, we describe a CRISPR-based assay that detects mutations in spike gene CRISPR PAM motif or seed regions to identify a pan-specific VOC single-nucleotide polymorphism (SNP)) ((D614G) and Alpha- and Delta-specific (S982A and D950N) SNPs.

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