Method: pS-B.1.1.7 and pS-B.1.351 plasmids were constructed with mutant S genes expressing the spike protein of the B.1.1.7 variant (GenBank: QQH18545.1, containing the H69, V70, and Y145 deletions and N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H mutations) and B.1.351 variant (GenBank: QRI43207.1, containing the L242, A243, and L244 deletions and L18F, D80A, D215G, S305T, K417N, E484K, N501Y, D614G
Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.
Introduction: The Alpha (B.1.1.7) variant encodes an S protein with nine mutations (del 69-70, Del 144, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), of which N501Y is in the receptor-binding domain (RBD).
Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Table: S982A
A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands.
Discussion: This lineage is defined by 14 amino acid changes and three deletions, including six amino acid substitutions and two deletions in the spike protein: S:DeltaH69-V70, S:DeltaY144, S:N501Y, S:A570D, S:P681H, S:T716I, S:S982A, and S:D1118H and it has been related with some evolutionary advantages such as an increased transmissibility.
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
Result: The III wave was characterized by the appearance of the subset of mutations that distinguish the B.1.1.7 lineage such as H69_V70del, Y144del, N501Y, A570D, P681H, T716I, S982A, and D1118H.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Cell discovery
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