Result: The relative abundance of each marker from most to least abundant was D614G > A570D > 69-70del and 144del > D1118H > S982A > P681H and T716I > N501Y > E584K (Table 2).
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.
Result: Mutations of P681 R/H, D950 N, T716I, S982A, Q1071H, and D1118H were located in proximity to the S1/S2 cleavage site.
Result: Three (3.6%) sequences belonged to the Alpha variant (lineage B.1.1.7/clade GR/501Y.V1) and showed a mutational pattern of N501Y, A570D, D614G, P681H, T716I, S982A, D1118H, and three deletions of H69, V70, and Y144.
Discussion: Alpha variant B.1.1.7 was found in one case each from vaccine breakthrough, mild and dead patient category showing nonsynonymous muta
Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.
Introduction: Announced in December 2020 and probably emerging in November 2020, the Alpha variant, the most commonly isolated variant worldwide, is characterized by the presence of the N501Y, A570D, P681H, T716I, S982A, and D1118H substitutions and deletions at positions 69/70 and 144 in the S gene.
Table: S982A
Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of Concern.
Discussion: We have shown that the molecular mechanism underlying the fitness advantage of Alpha in vivo is largely dependent on a few changes in S, including three amino acid deletions (H69, V70 and Y144) and six substitutions (N501Y, A570D, P681H, T716I, S982A and D1118H).
Pierce into Structural Changes of Interactions Between Mutated Spike Glycoproteins and ACE2 to Evaluate Its Potential Biological and Therapeutic Consequences.
PMID: 34931119
2022
International journal of peptide research and therapeutics
Result: According to the results of the multiple sequence alignment, the mutations of the EPI_ISL_601443 variant were as follows: H69 deletion, V70 deletion, Y144 deletion, N501Y substitution, A570D substitution, D614G substitution, P681H substitution, T716I substitution, S982A substitution, and D1118H substitution.
Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants.
PMID: 34545316
2022
Journal of pharmaceutical analysis
Introduction: This variant is defined as lineage B.1.1.7 and has multiple spike protein amino acid deletions and mutations, such as deletion 69-70, deletion 144, and mutations N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.
Analysis of SARS-COV2 spike protein variants among Iraqi isolates.
Abstract: The most frequently mutations occurred at the D614G (87/91), followed by S982A (50/91), and A570D (48/91), respectively.
Abstract: Twenty-two distinct mutations were identified within the spike protein regions which were: L5F, L18F, T19R, S151T, G181A, A222V, A348S, L452 (Q or M), T478
Result: Other predominant mutations which appeared frequently among Iraq isolates were S982A (55%), A570D (53%), P681H (52%), D1118H (51%).
SARS_CoV_2 mutation literature information.
PMID: 
2022
Biomedicine & pharmacotherapy
Browser Board
Co-occurred Entities
Filtrator
ViMRT