Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects.
PMID: 35096288
2022
Computational and structural biotechnology journal
Result: The Spike D614G/S939F double mutation is poorly studied and consequently its impact on host infection and patient clinical implications are scarcely known.
Result: We found that S939F variant was detected in Sweden and Denmark when we evidenced S939F-D614G double mutation in our patient samples.
Result: Worldwide geographically distribution of double Spike mutation D614G/S939F.
Result: we can identify a small number of peptides that are either present exclusively in the reference protein (16 for D614G and 20 for S939F) or in the mutated protein (16 for PMID: 33495741
2021
Heliyon
Table: S939F
Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus).
Conclusion: Alternatively, mutations H146Y (24 cases), V483A (11 cases), E554D (14 cases), P681L (16 cases) and S939F (11 cases) all occur only in USA or mutation L8V (4 cases) occurs only in Hong Kong (refer to the spreadsheet data, which can be found in the Data Availability section).
Table: S939F
Structural stability predictions and molecular dynamics simulations of RBD and HR1 mutations associated with SARS-CoV-2 spike glycoprotein.
PMID: 33618621
2021
Journal of biomolecular structure & dynamics
Abstract: We have studied the impact of mutations such as A348T, N354D, D364Y, G476S, V483A, S494D in the RBD (319-591), and S939F, S940T, T941A, S943P (912-984) in the HR1 domains of spike glycoprotein.
SARS-CoV-2 genomic analyses in cancer patients reveal elevated intrahost genetic diversity.
Result: Another 85 SNVs were observed in our consensus sequences at lower frequency (1.4%-19.7%; Supplementary Table S2), including nine non-synonymous mutations in S protein (V16F, V367L, K558N, Q675H, A879V, S939F, V1176F, K1191N, and G1219V).
D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect.
Result: In particular, S929T is mainly associated with the GV clade and D936Y is mainly associated with the GH clade, while S939F is roughly equally associated with the GR, GH, GV, and G clades.
Discussion: On 15 February 2021, D936Y was the most frequent mutation on the HR1 fusion core, followed by S939F and S929T.
Discussion: While the geographical distribution of S929T, mostly from England, and of S939F, mostly from England, USA, and Denmark, may reflect the higher contribution of these countries to the genomic sequencing of SARS-CoV-2 (the three countries together covered roughly two-thirds of the sequences in GISAID on 15 February), D936Y was widespread.
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.
Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach.
PMID: 34346317
2021
Computers in biology and medicine
Table: S939F
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
SARS_CoV_2 mutation literature information.
PMID: 
2022
Computational and structural biotechnology journal
Browser Board
Co-occurred Entities
Filtrator
ViMRT