literature

SARS_CoV_2 mutation literature information.

Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipeline.

PMID: 32954666 2021 Transboundary and emerging diseases

Result: We found mutations in the variable regions between SARS-CoV-2 and RaTG13, and these recurrent mutations (S50L, T76I, A372T, N439K) are supposed to be converted to RaTG13 from SARS-CoV-2 (Table S1).

Systemic effects of missense mutations on SARS-CoV-2 spike glycoprotein stability and receptor-binding affinity.

PMID: 33006605 2021 Briefings in bioinformatics

Result: Mutations of S50L (DeltaDeltaG = -2.614 kcal/mol), T724I (DeltaDeltaG = -2.590 kcal/mol) and T240I (DeltaDeltaG = -2.476 kcal mol) have strong stabilizing effects on SARS-Cov-2 full-length S protein.

Table: S50L

Discussion: S50L in seven strains and V341I have the minimum DeltaDeltaG among all other possible mutations in their positions (Supplementary Figure 5).

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Result: Based on 760 whole sequences from Oceania and South America, the most common mutations are found to be G1124V (25 mutations) and D614G (20 mutations), while other different mutations tend to increase, such as S50L (10 mutations), A262T (11 mutations), L5F (5 mutations), D138H (3 mutations), S221L (3 mutations), G485R (3 mutations) (Table 3).

Table: S50L

Functional and Structural Characterization of SARS-Cov-2 Spike Protein: An In Silico Study.

PMID: 34158771 2021 Ethiopian journal of health sciences

Table: S50L

Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.

PMID: 34271250 2021 Biomedical journal

Table: S50L

Discussion: We found 17 mutation types of total sequences located within the NTD including T22I, P25L, T29I, Y38C, H49Y, S50L, F86S, T95I, E96G, S151G, N185K, N188K, V213L, S221W, S247R, G261D and Y279N.

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: S50L

Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma.

PMID: 34319130 2021 mSphere

Result: Of note, two SNPs (T21570G and C21771T, leading to spike

Table: S50L

Discussion: Although no experimental data are available about the functional role of S50L (which falls within the spike N-terminal domain, NTD), recent computational analysis suggests that it might have strong stabilizing effects on SARS-Cov-2 full-length spike protein.

Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach.

PMID: 34346317 2021 Computers in biology and medicine

Figure: S50L nonsynonymous mutant S-protein residue interaction with ACE-2 receptor prepared by Ligplot.

Figure: Native and nonsynonymous stabilizing mutations (H49Y, S50L, N501Y, D614G, A845V, and P1143L) of S-protein i

Discussion: The stabilizing nonsynonymous mutations (H49Y, S50L, N501Y, D614G, A845V, and P1143L) of the S-protein have a better binding affinity with ACE2 receptor complexes with the native complex (Table 4b).

Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals.

PMID: 34910734 2021 PloS one

Result: Similarly, lions have some unique mutations like E583V, G496D, S50L, Q613R, A623T, Y505H, A623I (Fig 12).

Browser Board

Co-occurred Entities

Filtrator