Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Result: Among the mutations in RBD, R346K, N440K, G446V, N450K, V483F, E484K, E484Q, F490S and S494P also showed change in ACE2 binding to the extent of 75% to 90%.
Result: Variants identified with mutations at sites such as E484 (E484Q), F490 (F490S), Q493 (Q493STOP), and S494 (S494P) in the RBD are presumed to have immune escape features.
Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.
Abstract: Irrespective of the geographical region, in the case of the adaptive mutations, N501Y (48.38%) was found to be the dominant mutation followed by L452R (17.52%), T478K (14.31%), E484K (4.69%), S477N (3.29%), K417T (1.64%), N439K (0.7%) and S494P (0.7%).
Method: Some adaptive mutations, namely Y453F, S477N, T478K, E484K, S494P and N501Y, were also found in long-term COVID-19 infections.
Result: During this period,
The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America.
3Introduction: Moreover, we have pointed out that Y449S and Y449H are two vaccine-resistant mutations, and ""Y449S, S494P, K417N,
Introduction: Later on, we have provided a list of most likely vaccine escape RBD mutations with high frequency, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.
Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies.
Figure: Change in binding free energy (DeltaDeltaG = DeltaGWILD-TYPE - DeltaGMUTANT) predicted by computational mutagenesis of the S-RBDCoV-2 wild-type residues E484 (A), Q493 (B), S494P (C), V483 (D), F486 (E), Y489 (F), Y449 (G), L452 (H), T470 (I), and F490 (J) for the corresponding S-RBDCoV-2/LY-CoV555 mAb complexes.
Discussion: Spike variants identified in these studies that presented reduced susceptibility to the LY-CoV555 mAb included the following substitutions: E484D/K/Q, F490S, Q493R, and S494P.
Discussion: Remarkably, the spike S494P mutation is a component of the B.1.17 + S494P
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
Introduction: A list of vaccine-escape (vaccine-breakthrough) mutations was tabulated in our early work, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.
Introduction: Many of these co-mutation sets involve vaccine-escape mutations predicted in our early work: S494P, Q493L, K417N, F490S, F486L, R403K, PMID: 34543625
2021
The Journal of biological chemistry
Table: S494P
Figure: Panels A-I show the data for the wild-type RBD, single amino acid mutations K417N, Y453F, S477N, T478I, E484K, S494P, N501Y, and for the triple mutant K417T/
Figure: The single mutants of RBD used in this study were K417N, N439K, Y453F, S477N, T478I, E484K, S494P and N501Y (Alpha variant).
Emergence of SARS-CoV-2 Variant B.1.575.2, Containing the E484K Mutation in the Spike Protein, in Pamplona, Spain, May to June 2021.
PMID: 34495709
2021
Journal of clinical microbiology
Introduction: The B.1.575.1 sublineage was classified in the Phylogenetic Assignment of Named Global Outbreak (PANGO) lineage system as a Spanish sublineage of B.1.575 with spike mutations P681H, S494P, and T716I, and the B.1.575.2 sublineage, whose main characteristic is the presence of the E484K spike mutation, also originated in Spain.
Result: Among the common substitutions present in these lineages, four occurred in the spike protein (S494P, D614G, P681H, and T716I).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of global infectious diseases
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