Abstract: The most common sets of spike mutations in this lineage (now designated as B.1.526) are L5F, T95I, D253G, E484K or S477N, D614G, and A701V.
Result: Regarding four of the spike mutations prevalent in this lineage: (1) E484K is known to attenuate neutralization of multiple anti-SARS-CoV-2 antibodies, particularly those found in class 2 anti-RBD neutralizing antibodies, and is also present in variants B.1.351 and P.1/B.1.1.248, (2) D253G has been reported as an escape mutation from antibodies against the N-terminal domain, (3)
Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.
Result: However, during the second wave starting from October 2020 substitution point mutations E780Q, K417N, T478I, N501Y, E484K, N439K, V1176F, S477N and A222V became common at spike protein in the isolates in Japan.
Table: Discussion: Variants with substitutions namely, K417N, T478I, N501Y, E484K, N439K and S477N at RBDs have been detected recently in Japan.
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.
Result: Fifteen variants with the prevalence >5% were identified, including (i) four variants in nucleocapsid: S194L (6.29%), R203K (28.45%), G204R (
Discussion: Additionally, other variants like S25L in NSP7, S194L, R203K, G204R, and T205I in nucleocapsid, T85I and I120F in NSP2, S477N in spike, and Q57H in ORF3a have also been confirmed by previous studies.
A Sanger-based approach for scaling up screening of SARS-CoV-2 variants of interest and concern.
PMID: 33975021
2021
Infection, genetics and evolution
Table: S477N
Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?
PMID: 33975397
2021
Journal of Korean medical science
Method: Among these mutations, five (L18F, S98F, A262S, A222V, and P272L) occurred in the N-terminal domain (NTD) of the S protein, and five (N439K, Y453F, S477N, E484K, and N501Y) appeared in the S protein RBD.
Method: In addition, the D614G, S477N, and E484K mutants of the S protein are considered to pose a risk of immune escape or increased ACE2 binding by the v
Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility.
Result: Averaged affinities predicted by structural modeling indicate that the mutations fall into three groups (Figure 6 (a)): very high-affinity (80 to 90% better that WT; S477N/E484K/N501Y, S477N/E484K and E484K/N501Y), high-affinity (40 to 50% better than WT; S477N, E484K, N501Y), WT-like (S477N/N501Y, K417T/E484K/N501Y, N439K, Y453F), and low-affinity (<70% of WT; K417T<
Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries.
Abstract: In particular, we discover new fast-growing RBD mutations N439K, S477N, S477R, and N501T that also enhance the RBD and ACE2 binding.
Introduction: We show that in addition to mutations N501Y, E484K, and K417N in the UK, South Africa, and Brazil(ian) variants, L452R, E484Q in the India variants, N439K, S477N, S477R, and N501T are also fast-growing mutations in 31 pandemic-devastated countries in the past few months.
Result: 13 , shows that, in ad
Novel SARS-CoV-2 variants: the pandemics within the pandemic.
PMID: 34015535
2021
Clinical microbiology and infection
Method: Other remarks: This variant contains multiple mutations, notably S477N or E484K near the RBD - but not both at the same time.
An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.
Discussion: In addition, this study observed the presence of individual amino acid variants in the SARS-CoV-2 variants B.1.1.7 (S494P), B.1.525 (A67V, Q677H), B.1.526 (L5F, T95I, S477N), and P2 (V1176F) in the earlier samples.
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.
Discussion: Currently, besides the D614G variant, several mutations within the receptor binding domains (RBD) of the S protein have attracted most scientists' attention due to their increased frequency in certain countries, including S477N (Australia and some Central European), N439K (UK and European), and N501Y (part of the new UK variant B.1.1.7, the new South Africa variant 501.V2 and the new Brazil variant P.1).
SARS_CoV_2 mutation literature information.
PMID: 
2021
bioRxiv
Browser Board
Co-occurred Entities
Filtrator
ViMRT