Abstract: Molecular docking analysis revealed that G462D/G462S variants were predicted to be protective variants, whereas Q438E and S339F variants were predicted to increase susceptibility.
Result: 450 nM) (Table 1), whereas the S339F variant had a marginal increase affinity at cleavage site two (KD, 20 nM vs.
Result: Another variant that established direct contact with the S protein was S339F, where it formed a hydrogen bond with Q872.
Discussion: In contrast, the Q438E and S339F variants improved binding affinities to the S glycoprotein at cleavage sites one and two, respectively.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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