literature

SARS_CoV_2 mutation literature information.

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Result: ORF8 variants having S24L mutations are only observed in viral samples from the USA.

Table: S24L

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Result: The NS8_S24L mutation was reported at 33.88% in SARS-CoV-2 genome sequences isolated from North America.

Mutations in SARS-CoV-2 ORF8 Altered the Bonding Network With Interferon Regulatory Factor 3 to Evade Host Immune System.

PMID: 34335535 2021 Frontiers in microbiology

Abstract: Since several mutations in ORF8 have been observed, therefore, in the present study, we adapted structural and biophysical analysis approaches to explore the impact of various mutations of ORF8, such as S24L, L84S, V62L, and W45L, the recently circulating mutant in Pakistan, on its ability to bind IRF3 and to evade the host immune system.

Method: Amber20 was used to perform the dynamic behavior analysis of ORF8 WT and ORF8 with mutations of S24L, W45L, V62L, and L84S through MD simulation that uses FF14SB force field.

Method: The Chimera software was us

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.

PMID: 34147651 2021 Infection, genetics and evolution

Result: Additionally, S24L (PF = 2.2%) and V62L (PF = 1.2%) are the moderately recurring mutations in ORF8.

Result: Among the moderately recurring mutations, following mutations are found in the hospitalized patients in the following order of frequency: ORF8:L84S > ORF3a:G251V > ORF8:S24L > N protein: S197L > Nsp4:F308Y.

Result: Some notable substitutions, co-occurring mutations, deletions and insertions which occur with a low to moderate recurrence and may have a significant influence on the viral pathogenic mechanism are: co-deletion (dependent) of K141,

Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.

PMID: 33966351 2021 Transboundary and emerging diseases

Table: Ser24Leu

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.

PMID: 33925854 2021 Microorganisms

Result: The COH-VOC has two mutations at positions N501Y and D614G in the S-protein, while harboring several mutations in the NSP2 (T85I), NSP3 (T181I, A256V), NSP5 (L89F, P108S), NSP6 (G258E), NSP12 (P323L), NSP14 (N129D), and NSP16 (R216C), NS3 (Q57H, G172V), NS7a (

Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.

PMID: 33920487 2021 Biomedicines

Result: Fifteen variants with the prevalence >5% were identified, including (i) four variants in nucleocapsid: S194L (6.29%), R203K (28.45%), G204R (28.13%), and A220V (25.96%); (ii) four variants in spike: L18F (12.08%), A222V (26.14%), S477N (6.62%), and D614G (93.88%); (iii) two variants in NSP2: T85I (15.38%) and I120F (5.23%); (iv) five variants in each of the 5 proteins: L37F (6.52%) in NSP6, P323L (93.74%) in

Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.

PMID: 33908339 2021 Epidemiology and infection

Result: Significant correlation was detected between NSP5_G15S and UV (rs = 0.91), followed by NS8_S24L and maximum temperature (rs = 0.51), NSP3_T1198K and RH (rs = 0.45), respectively (Table 5).

Table: S24L

Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity.

PMID: 33900399 2021 JAMA network open

Result: Several variants were associated with lower hospitalization rate, including 12809C>T (L4182F ORF1ab, 3 of 91 hospitalizations [3.3%] vs 22 of 211 hospitalizations [10.4%]; chi21 = 4.215; P = .04) and 27964C>T (S24L ORF8, 0 of 91 hospitalizations [0%] vs 13 of 211 hospitalizations [6.2%]; chi21 = 5.878; P = .01).

Whole genome analysis of more than 10 000 SARS-CoV-2 virus unveils global genetic diversity and target region of NSP6.

PMID: 33725111 2021 Briefings in bioinformatics

Table: S24L

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