literature

SARS_CoV_2 mutation literature information.

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Table: S24L

An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.

PMID: 34272947 2022 Clinical infectious diseases

Result: Of the 93 substitutions that were present in 2020, 61 were no longer present during March 2021 (Figure 5C), and only 8 were present in >5% of samples during March 2021 (NSP2:T85I, NSP12:P323L, S:L5F, S:D614G, NS3aQ57H, NS8:S24L, N:R203K, and N:G204R).

Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk.

PMID: 35075180 2022 Scientific reports

Table: S24L

Worldwide SARS-CoV-2 haplotype distribution in early pandemic.

PMID: 35171928 2022 PloS one

Table: p.Ser24Leu

An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2.

PMID: 35341060 2022 PeerJ

Discussion: Within North America, it was reported that one of the top mutations, 27964C>T-(S24L) in the ORF8 protein, has an unusually strong gender dependence.

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8.

PMID: 35343786 2022 mBio

Result: Correspondingly, the L84S variant failed to induce CCL20, CXCL1, and IL6 expression, whereas the V62L and S24L variants induced detectably lower expression of CCL20, CXCL1, and IL6 compared to WT ORF8.

Result: The S24L and V62L variants also showed detectable reduction of the surface binding activity to THP-1 and hIL-17RA-expressing 293T cells but minor changes of the surface binding activity to hIL-17RC-expressing 293T cells.

Result: Three variants, S24L, V62L, and L84S, the most frequently emerged ORF8 variants in America.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: In the US, Q57H mutation in the ORF3a region, and S24L and L84S in ORF8 was found to be prevalent, suggesting a positive effect on transmission or virulence.

Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.

PMID: 34356077 2021 Genes

Result: The NS8_S24L mutation was reported at 33.88% in SARS-CoV-2 genome sequences isolated from North America.

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Result: ORF8 variants having S24L mutations are only observed in viral samples from the USA.

Table: S24L

Mutations in SARS-CoV-2 ORF8 Altered the Bonding Network With Interferon Regulatory Factor 3 to Evade Host Immune System.

PMID: 34335535 2021 Frontiers in microbiology

Abstract: Since several mutations in ORF8 have been observed, therefore, in the present study, we adapted structural and biophysical analysis approaches to explore the impact of various mutations of ORF8, such as S24L, L84S, V62L, and W45L, the recently circulating mutant in Pakistan, on its ability to bind IRF3 and to evade the host immune system.

Method: Amber20 was used to perform the dynamic behavior analysis of ORF8 WT and ORF8 with mutations of S24L, W45L, V62L, and L84S through MD simulation that uses FF14SB force field.

Method: The Chimera software was us

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