literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.

PMID: 35386683 2022 Frontiers in cellular and infection microbiology

Result: Notably, all the mutations associated with the recovered group (S2015R, Y789Y, T2016K, S194*, A4489V) showed a frequency flip, whereas two mutations associated with the mortality group showed a shift in their frequency from our cohort to global level.

Discussion: Moreover, a significant frequency flip (p-value = 0.0001) was seen for the five mutations, S2015R, Y789Y, T2016K, S194*, and A4489V, in the recovered with a low global presence, indicating that the mutations associated with COVID-19 recovery are deselected by the virus during its evolution.

A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.

PMID: 33705994 2021 Computers in biology and medicine

Table: S2015R

Discussion: Our study found P2144S, A1812D, and S2015R mutations in PLPro affecting the structural characteristics of this enzyme in Kerala (IND/29) and Himachal Pradesh isolates.

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