literature

SARS_CoV_2 mutation literature information.

In Silico Investigation of the New UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 Variants with a Focus at the ACE2-Spike RBD Interface.

PMID: 33567580 2021 International journal of molecular sciences

Discussion: In that study, the authors found that two substitutions in ACE2 positions 19 and 26 could modulate the affinity for the Spike protein (ACE2 position 19, fully solvent exposed:the S19P is common in African people and the substitution was suggested to protect individuals (reduced affinity for Spike) and a cleavage site of the ACE2 precursor; ACE2 position 26, fully solvent exposed:the K26R is common in European people, the mutation may increase affinity of ACE2 towards Spike).

Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach.

PMID: 34720581 2021 Bioinformatics and biology insights

Result: S19P variant of ACE2 showed relatively less binding affinity (-12.1 kcal/mol) compared with wild-type complex.

ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients.

PMID: 33108902 2020 Cell transplantation

Abstract: Variants were present at low frequency (range 0% to 3%) and among those with the highest frequency, the variant S19P belongs to the SARS-CoV-2 spike protein binding site and it was exclusively present in Africans with a frequency of 0.2%.The mechanisms of ACE2 and TMPRSS2 regulation could be targeted for preventive and therapeutic purposes in the whole population and especially in cancer patients.Further studies are needed to show a direct correlation of ACE2 and TMPRSS2 expressions in cancer patients and the incidence of COVID-19.

Result: Interestingly, among those with the highest frequency, the variant S19P belongs to the SARS-CoV-2 spike protein binding site and it was exclusively present in Africans with a frequency of 0.2%.

Discussion: In particular, the ACE2 variants

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