Result: Among 22 point mutations at N and other eight non-structural proteins, eight namely, N_S194L, N_R203K, N_G204R, NS3_Q57H, NSP2_T85I, NSP5_G15S, NSP6_L37F and NSP12_P323L were persistent throughout the COVID-19 pandemic in Japan.
Table: S194L
Discussion: About all of the isolates in Japan contained D614G at spike proteins, N_
Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China.
Method: data, https://doi.org/10.1101/2020.10.27.357558), including mutations in the RNA-dependent RNA polymerase (RdRp[L323P]), Spike(D614G), open reading frame 3a (ORF3a[Q57H]), ORF3b(E14*), and nucleocapsid (N[S194L]) proteins.
Genomic Variations in SARS-CoV-2 Genomes From Gujarat: Underlying Role of Variants in Disease Epidemiology.
Abstract: Among the missense mutations present in the Gujarat SARS-CoV-2 genomes, C28854T (Ser194Leu) had an allele frequency of 47.62 and 7.25% in deceased patients from the Gujarat and global datasets, respectively.
Figure: Distinct cluster of the viral isolate with mutation C28854T/Ser194Leu/N gene in Gujarat SARS-CoV-2 genomes.
Whole genome analysis of more than 10 000 SARS-CoV-2 virus unveils global genetic diversity and target region of NSP6.
Abstract: Previously reported mutations including D614G in S gene, P4715L in ORF1ab, S194L, R203K, and G204R in N gene were identified in the genomes sequenced in this study.
Result: N gene mutations idenfied in this study (S194L, R203K, and G204R) are located in the region 180-247, which is suggested to be a flexible linker region that lacks organized structure.
Result: Oklahoma-ADDL-4, carried a non-synonymous mutation S194L while Oklahoma-ADDL 2,3,5 carried R203K and
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
Result: Intriguingly, 28854C>T (S194L) in the N gene was found to coevolve with the 22444C>T (D294D) mutation in the S gene of 11 samples in the major group (Table 1).
Result: Out of the 67 isolates of the major group, 28 revealed 4 novel mutations: 28854C>T (S194L; n=13), 28881-28883GGG>AAC (R203K and G204R; n=13), and coevolving mutation 29451C>T (T393I) and 28395G>A (R41R; n=2) in the N gene (Table 1).
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.
Result: Notably, many of these mutations correspond to a loss of potential phosphorylation sites (serines and threonines), namely, Ser188Leu, Ser193Ile, Ser194Leu, Ser197Leu, Ser202Asn(Ile), and Thr205Ile.
Result: The wavelet analysis simultaneously displays the location, frequency, and mutational density at different scales and identified a cluster of moderately frequent mutations involving 14 amino acids in a serine/arginine-rich motif of N (Ser180Ile, Ser183Tyr, Ser188Leu, Ser190Asn, Ser193Ile, Ser194Leu,
Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.
Result: The remainder was found in the core phosphoprotein (S193I, S194L, S197L, S202N, R203K, and G204R), membrane glycoprotein (D3G, T175M), ORF3a (Q57H, H93Y, G196V, and G251S V62) and ORF62884).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Epidemiology and infection
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