Method: For two high-frequency non-synonymous nucleocapsid protein mutations (R203K and G204R; co-fixed), all but three of the 30 (N173-234) flanking residues have non-synonymous variants, with 5 sites reporting an alternative allele frequency greater than 1% (A220V, S194L, S197L, M234I and P199L:S).
Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week.
Result: In the regional analysis, the most frequent N mutations were the already mentioned D103Y, S194L, and S197L in Europe (3.2%, 2.8%, and 2.3%, respectively), S194L in North America (4.3%); P13L and S194L in Asia (15% and 6.4%), and P13L and S197L in Oceania (5.7% and 4.8%, respectively).
Result: It was the case for S197L (1.7%, 1686 sequences, 56% from Spain), P13L (1.8%, 1782 sequences, 62% from India and Singapore and 21% from Australia), D103Y (1.9%, 1863 sequences, 89% from England), S194L (3.2%, 3194 sequences, 39% from England an
Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus).
The extent of molecular variation in novel SARS-CoV-2 after the six-month global spread.
PMID: 33677109
2021
Infection, genetics and evolution
Result: Moreover, subclade 2C variant with the changes at Spike D614G, ORF3a Q57H, and nucleocapsid S194L (GenBank: MT630421) was first reported in Saudi Arabia on March 15.
Result: Most subclade 2C variants (92.86%) with the amino acid changes at Spike D614G, ORF3a Q57H, and Nucleocapsid S194L was prevalent in Asia counties, including India (61/70), Bangladesh (3/70), and Saudi Aribia (1/65) (Supplemental.
Table: S194L
Discussion: Beside the amino acid substitutions occurred at SARS-CoV-2
A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.
PMID: 33705994
2021
Computers in biology and medicine
Table: S194L
Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2.
Result: However, the 10 amino acid substitutions recurred in SARS-CoV-2, i.e., I789V of papain-like protease, H36Y and V354F of spike-S1, G251V of ORF3a, D209H of membrane glycoprotein, V62L, L84S, and P85S of ORF8, and S194L, S202N, and P344S of nucleocapsid phosphoprotein (Figure 3E).
Result: In addition, epidemiological and evolutionary data for H36Y, N341D
Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.
Discussion: Many other missense and synonymous mutations found in respective proteins of Bangladeshi virus populations such as ORF1ab/nsp12_P323L, NS3_Q57H, NS8_R52I, N_S194L, N_R203K, and N_G204R, which are also common worldwide.
SARS-CoV-2 mutations: the biological trackway towards viral fitness.
Result: Fifteen variants with the prevalence >5% were identified, including (i) four variants in nucleocapsid: S194L (6.29%), R203K (28.45%), G204R (28.13%), and A220V (25.96%); (ii) four variants in spike: L18F (12.08%), A222V (26.14%), S477N (6.62%), and D614G (93.88%); (iii) two variants in NSP2: T85I (15.38%) and I120F (5.23%); (iv) five variants in each of the 5 proteins: L37F (6.52%) in NSP6, P323L (93.74%) in
SARS_CoV_2 mutation literature information.
PMID: 
2021
Genome medicine
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