literature

SARS_CoV_2 mutation literature information.

Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals.

PMID: 34910734 2021 PloS one

Result: Other commonly found mutations were Y453F (50.3%), S194L (49.4%), R203K (49.1%), and G204R (47.6%) in N protein of mink (Fig 13).

Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.

PMID: 34726786 2021 Journal of medical virology

Table: S194L

Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome.

PMID: 34606987 2021 Infection, genetics and evolution

Result: In addition, very high rate recurrent mutations exist at the following locations: spike protein; D614G, nucleocapsid phosphoprotein; S194L, R203K and G204R, ORF3a; Q57H and G251V, and ORF8; L84S.

Result: The following mutations: N protein (P13L and S194L), ORF8 (L84S), nsp3 (T2016K), and nsp6 (

Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA Structure.

PMID: 34578142 2021 Pathogens (Basel, Switzerland)

Result: During the protein structure analysis, we observed a minor change in polarity due to the T268S (Figure S1) and S194L (Figure S2) with no significant change in the physicochemical properties.

Result: For S194L mutation, coils were turned into sheets (Figure 5).

Result: Mutation S194L was found to be located in the serine-arginine (SR)-rich motif of N protein.

Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.

PMID: 34464419 2021 PloS one

Result: In N gene, the most frequent ns-SNV were R209I and S194L where in the S-gene the most frequent ns-SNV was D614G (S2 Table).

Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.

PMID: 34458642 2021 Heliyon

Table: S194L

Discussion: The S194L was predicted to have neutral effect in our study with a reduced DDG value and may attenuate viral assembly as reported in an earlier study.

Discussion: There two other functionally significant mutations which are Q57H in ORF3a and S194L in N protein.

Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.

PMID: 34445204 2021 International journal of molecular sciences

Result: Finally, a significant growing trend from 7% in September to 27% in October/November samples was revealed for the missense mutation S194L (28854C>T), in line with a similar trend observed worldwide (09/2020, 13% and 11/2020, 21%).

Result: Similar to R203K, the S194L mutation is also located on the SR-rich motif of the N protein and involves substitution of the hydroxylic neutral serine with the aliphatic neutral leucine.

Result: Since this region regulates the N protein oligomerization upon phosphorylation, the S194L could have a significant impact on protein function; this notion is in accordance with the dramatic changes in the predicted protein structure, and therefore merits further study.

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Result: Consistent with this study, we identified R203K, G204R, S194L, and M234I in the nucleocapsid protein as shared mutations between Columbia and Rock Hill WWTP influents in January 2021 (Supplementary Table S3).

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Result: The most frequent amino acid substitutions were observed in the nucleocapsid (N) protein, in which the variants S194L, D103Y, P13L, S197L, M234I, and S188L were predicted to be stabilizing according to both the analytical servers (Table 2).

Table: S194L

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.

PMID: 34147651 2021 Infection, genetics and evolution

Result: Among these, S193I, S194L and S197L recur with the percentage frequency in the range of 1 to 1.6% (moderate recurrence).

Result: Some notable substitutions, co-occurring mutations, deletions and insertions which occur with a low to moderate recurrence and may have a significant influence on the viral pathogenic mechanism are: co-deletion (dependent) of K141, S142 and F143, co-deletion (dependent) of G82 and H83, D75E, co-occurring (dependent) S135N, Y136 deletion and M85 deletion in Nsp1, D268 deletion, G212D, co-occurring (dependent) I559V and P585S, F10L, V198I, P91S, T16

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