SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.
PMID: 35386683
2022
Frontiers in cellular and infection microbiology
Discussion: Also, the mutation S194L found in the Nucleocapsid gene was a highly significant mutation observed across our cohort and is also associated with mortality.
Discussion: Although mutation S194L is previously reported to be associated with mortality as seen in our cohort, its effect on the protein structure has not been explored and elucidated.
Discussion: The MD simulations performed for the mutations S194* and S194L from the recovered and mortality group, respectively, revealed RMSD values, which was evaluated for both the mutations and the wild-type, implying a state of equilibrium achieved for all the three systems.
Discussion: This suggests the instability of the mutation S194* in the recovered group, which is exactly correlating with its low frequency
Severe breakthrough COVID-19 with a heavily mutated variant in a multiple myeloma patient 10 weeks after vaccination.
PMID: 34909634
2022
Clinical infection in practice
Discussion: Of the three nucleocapsid mutations noted in our isolate, S194L has been best characterized, and is associated with poorer clinical outcomes.
An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.
Result: Amino acid changes in hospitalized patients compared with all patients with >=10% prevalence and a 5% change between the 2 groups showed that 4 mutations (S: P681H, NSP6: 106-108del, N: S194L, and N: T205I) were present to a higher degree, but not significantly higher or didn't reach statistical significance.
Discussion: It was also the only lineage with the occasional co-occurrence of N:T205I and N:S194L, which were both seen in higher percentages of sequences from known hospitalized patients.
Discussion: This lineage shows amino acid substitutions NSP12
Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.
PMID: 34968862
2022
Computers in biology and medicine
Result: Interestingly, among all recurrent mutations in structural protein, the spike protein has one D614G (82%), nucleocapsid had three S194L (20%), R203K (14%), G204R (14%) R209I (25%) mutation hotspot.
Table: S194L
Worldwide SARS-CoV-2 haplotype distribution in early pandemic.
In-silico genomic landscape characterization and evolution of SARS-CoV-2 variants isolated in India shows significant drift with high frequency of mutations.
PMID: 35233173
2022
Saudi journal of biological sciences
Result: The third common mutation- 299/546 (54.8%) occurred in ORF3a at position 25,563 where G changed to T leading to- Q75H, followed by a mutation in N gene at position 28,854 where C changed to T leading to S194L) Table 3 and.
Table: S194L
Discussion: The third common mutation occurred in ORF3a at position G 25563 T (Q75H) followed by a mutation in the N gene at position C28854T (S194L).
Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk.
Discussion: Among these six SNVs, four nucleotides (c28854, g28881, g28882, g28883) were non-synonymous and code residues S194L, R203K, R203S and G204R, respectively, in Nucleocapsid, and two nucleotides (t19839, a20268) in endoRNase of orf1ab encoded synonymous changes (N73N and L216L, respectively).
Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.
Result: In N gene, the most frequent ns-SNV were R209I and S194L where in the S-gene the most frequent ns-SNV was D614G (S2 Table).
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Discussion: The S194L was predicted to have neutral effect in our study with a reduced DDG value and may attenuate viral assembly as reported in an earlier study.
Discussion: There two other functionally significant mutations which are Q57H in ORF3a and S194L in N protein.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Frontiers in cellular and infection microbiology
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