Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Figure: Mutated amino acid positions shown in the human ACE2 receptor bound structure (PDB ID: 6acj) of SARS-CoV-2 spike protein (except L5F, S13I, Q14H, G75V, T76I, Y145del, H146Y, Q675 H/R, Q677H, N679K, I834V, R1185H and K1195N as the regions were not covered in the structure).
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G, PMID: 34536797
2021
Virology
Result: Both its NTD mutations, S13I and W152C, were less efficiently recognized by plasma compared to D614G.
Result: This VOI has two NTD mutations, S13I and W152C, both of which did not significantly impact this interaction.
The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.
PMID: 34547629
2021
Biochemical and biophysical research communications
Table: S13I
Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.
SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response.
PMID: 34639178
2021
International journal of molecular sciences
Abstract: These include mutations S13I and W152C, decreasing antibody binding, N460K, increasing RDB affinity, or Q498R, positively affecting both properties.
Conclusion: These include mutations S13I and
Conclusion: These include mutations S13I and W152C, decreasing antibody binding, N460K, increasing RDB affinity, or Q498R, positively affecting both properties.
Discussion: Crucially, variant Epsilon has additional mutations, S13I and W152C, resulting in severe decrease of neutralization for NTD-directed Abs, due to a new disulphide bond inducing a conformational change.
Re-emergence of Gamma-like-II and emergence of Gamma-S:E661D SARS-CoV-2 lineages in the south of Brazil after the 2021 outbreak.
Discussion: A neutralizing antibody activity study using convalescent serum from patients or serum from vaccinated individuals showed a 3-sixfold reduction against the B.1.429 variant, and furthermore, the neutralizing activity of mAbs targeting NTD was completely blocked due to the combined mutations S:S13I and S:W152C in that domain.
SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.
Result: The S13I and W152C mutations, which are situated in the N-terminal domain (NTD) of the Spike protein, have been implicated in escape from NTD-targeting monoclonal antibodies.
Result: The VRV-haplotype S13I-W152C-L452R (ICR-3) appeared in Fall 2020 and is rapidly becoming dominant in states on the West Coast, as well as appearing in selected southwestern and southeastern states (Figure 3C-F).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Heliyon
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