Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Result: 5D) share the same set of mutations on the
Result: S13I and L452R were detected separately in previous sequences, but W152C was not.
Figure: L18F, E484K, N501Y, D614G, H655Y, and V1176F are associated with the Gamma variant of concern, and S13I, W152C, L452R are associated with the Epsilon variant of concern.
Figure: The substitutions L452R and S13I appeared separately before the emergence of the variant, while W152C did not.
Estimation of Secondary Household Attack Rates for Emergent Spike L452R Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Detected by Genomic Surveillance at a Community-Based Testing Site in San Francisco.
Abstract: Certain viral lineages bearing spike mutations, defined in part by L452R, S13I, and W152C, comprised 54.4% of the total sequences from January, compared to 15.7% in November.
Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines.
Result: The mutations of S protein include S13I, W152C, and L452R.
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G, PMID: 34458642
2021
Heliyon
Figure: Mutated amino acid positions shown in the human ACE2 receptor bound structure (PDB ID: 6acj) of SARS-CoV-2 spike protein (except L5F, S13I, Q14H, G75V, T76I, Y145del, H146Y, Q675 H/R, Q677H, N679K, I834V, R1185H and K1195N as the regions were not covered in the structure).
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
Table: S13I
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Introduction: In January 2021, novel strains B.1.427/429, which contain S13I, W152C, L452R, and D614G mutations in the spike protein, were found in California (Figure 1A).
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.
Discussion: For epsilon variant, the two B.1.427 and B.1.429 lineages have the same spike protein mutations, inclunding S13I and W152C in the NTD and L452R in the RBD.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Vaccine
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