literature

SARS_CoV_2 mutation literature information.

Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease.

PMID: 33506644 2022 Transboundary and emerging diseases

Abstract: A missense (Q271R) and synonymous (R41R) mutation in the S and N proteins, respectively, were identified in 2/27 patients with severe COVID-19 but not in patients with mild or moderate disease (0/86; p = .05, Fisher's Exact Test).

Result: No statistically significant enrichments were identified (two tailed t-test), though missense (Q271R) and synonymous (R41R) mutations in the S and N proteins, respectively, were identified in 2/27 patients with severe COVID-19 but not in patients with mild or moderate disease (0/86; p = .05, Fisher's Exact Test).

Figure: Two mutations, Q271R and

The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.

PMID: 33496683 2020 JMIR bioinformatics and biotechnology

Result: Out of the 67 isolates of the major group, 28 revealed 4 novel mutations: 28854C>T (S194L; n=13), 28881-28883GGG>AAC (R203K and G204R; n=13), and coevolving mutation 29451C>T (T393I) and 28395G>A (R41R; n=2) in the N gene (Table 1).

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