Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine Development.
PMID: 32884216
2020
Journal of laboratory physicians
Abstract: Other mutations observed within RBD exhibiting low antigenicity were T323I, A344S, R408I, G476S, V483A, H519Q, A520S, A522S and K529E.
Result: Other speculated mutations in the putative epitopes lying within RBD showing less antigenicity were T323I, A344S, R408I, G476S, V483A, H519Q, A520S, A522S, and PMID: 32881907
2020
PloS one
Abstract: Indian strain showed mutation in spike glycoprotein at R408I and in replicase polyprotein at I671T, P2144S and A2798V.
Conclusion: Mutatio
Result: For instance, India, Finland, Australia, South Korea and Sweden SARS-CoV-2 isolates showed one amino acid change at 408 (Arginine to Isoleucine), 49 (Histidine to Tyrosine), 247 (Serine to Arginine), 221 (Serine to Tryptophan) and 797 (Phenylalanine to Cysteine), respectively (Table 2 and Fig 3C).
Result: The value of DeltaDeltaG show that the mutant R408I (0.49732107 kcal/mol) mutation was having stabilization effect on spike protein.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.
SARS_CoV_2 mutation literature information.
PMID: 
2020
Journal of laboratory physicians
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