Result: Infection of Caco-2 cells at low MOI showed that the R403T SARS-CoV-2 mutant replicated with significantly lower efficiency than WT virus.
Discussion: However, the previous finding that numerous residues in the SARS-CoV-2 S RBD are involved in the interaction with the hu
Discussion: Mutation of E37 in ACE2 reduced the levels of WT CoV-2 S-mediated infection to those obtained for the R403T CoV-2 S.
Discussion: This suggests that the interaction between R403 in the S protein and E37 in the ACE2 receptor is relevant for full infectiousness of SARS-CoV-2, although reduced expression levels and incorporation of the R403T mutant CoV-2 S may also contribute.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Nature communications
Browser Board
Co-occurred Entities
Filtrator