literature

SARS_CoV_2 mutation literature information.

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.

PMID: 33535027 2021 Cell host & microbe

Result: For the 2B04-resistant mutant E484A, we selected T345A, R346G, and K444E; for mutant E484K, we isolated R346K, A372T, and K444E; and for mutant F486S, we selected T345S.

Result: Two of the mutants (R346K and A372T) were not seen in our prior selection campaigns with 2H04 alone, although both variants exist in human isolates (Figure 6).

Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies.

PMID: 33880470 2021 bioRxiv

Abstract: We unveil, for the first time, that high-frequency mutations R346K/S, N439K, G446V, L455F, V483F/A, E484Q/V/A/G/D, F486L, F490L/V/S, Q493L, and S494P/L might compromise some of mAbs in clinical trials.

Unraveling the stability landscape of mutations in the SARS-CoV-2 receptor-binding domain.

PMID: 33911163 2021 Scientific reports

Table: R346K

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries.

PMID: 34004284 2021 Genomics

Table: R346K

Revealing the Threat of Emerging SARS-CoV-2 Mutations to Antibody Therapies.

PMID: 34273397 2021 Journal of molecular biology

Abstract: We unveil, for the first time, that high-frequency mutations R346K/S, N439K, G446V, L455F, V483F/A, F486L, F490L/S, Q493L, and S494P might compromise some of mAbs in clinical trials.

Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2.

PMID: 34403832 2021 Infection, genetics and evolution

Abstract: This strategy allowed us to identify the emergence of the B.1.621 lineage, considered a variant of interest (VOI) with the accumulation of several substitutions affecting the Spike protein, including the amino acid changes I95I, Y144T, Y145S and the insertion 146 N in the N-terminal domain, R346K, E484K and N501Y in the Receptor binding Domain (RBD) and P681H in the S1/S2 cleavage site of the Spike protein.

Introduction: In this study, we reported the emergence and spread of the novel B.1.621 lineage of SARS-CoV-2, a new VOI with

Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein.

PMID: 34419160 2021 Infectious diseases of poverty

Table: R346K

Emerging vaccine-breakthrough SARS-CoV-2 variants.

PMID: 34518803 2021 ArXiv

Result: Further, [R346K, E484K, N501Y] (Mu variant) has a BFE change of 0.768 kcal/mol and high antibody disruption count (60).

Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.

PMID: 34696404 2021 Viruses

Result: In T4, apart from the mutations identified in T3, mutations R346K, L452Q, L452R and T478K were observed.

Result: While R346K and L452R mutations were observed only in sequences from Iraq with a prevalence of 7.41% and 1.85%, respectively, the other two mutations were observed only in sequences from the USA, with each having a prevalence of approximately 0.009%.

Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.

PMID: 34880635 2021 Infection and drug resistance

Table: R346K

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