Abstract: We note certain RBD mutations that might further enhance Omicron's escape, and in particular advise careful surveillance of two subclades bearing R346S/K mutations with relevance for certain therapeutic antibodies.
Result: Several Omicron subclades have been detected with R346S and R346K mutations.
Result: The RBD of PMS20, a variant that was designed to escape neutralization from most convalescent and polyclonal sera, features similar class 3 mutations to Omicron at sites 440 and 445, yet also features an R346K mutation that Omicron lacks.
Discussion: Notably, clade of Omicron have the identified bearing R346K (15 descendants at the time of this writing) and R346S (5 descendan
SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.
Introduction: Also, the R346K substitution in the isolate, a putative escape mutation which may confer additional antibody resistance (https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/), is not found in the majority of Omicron genomes.
Introduction: Sequencing of the isolated virus confirmed it was the Omicron variant bearing the R346K mutation.
Neutralization of SARS-CoV-2 Omicron variant by sera from BNT162b2 or Coronavac vaccine recipients.
Abstract: METHODS: Omicron variant strains HKU691 and HKU344-R346K were isolated from patients using TMPRSS2-overexpressing VeroE6 cells.
Abstract: Only 20% and 24% of BNT162b2 recipients had detectable neutralizing antibody against the Omicron variant HKU691 and HKU344-R346K, respectively, while none of the Coronavac recipients had detectable neutralizing antibody titer against either Omicron isolate.
Abstract: RESULTS: The Omicron variant strain HKU344-R346K has an additional spike R346K mutation, which is present in 8.5% of strains deposited in GISAID database.
Abstract: The additional R346K mutation did not affect the neutralization susceptibility.
Abstract: There was no significant difference in the GMT between HKU691 and HKU344-
Chimeric crRNA improves CRISPR-Cas12a specificity in the N501Y mutation detection of Alpha, Beta, Gamma, and Mu variants of SARS-CoV-2.
Discussion: To further differentiate Alpha, Beta, Gamma, and Mu, other mutation sites in the Spike protein like 69-70 deletion or 144 deletion, 242-244 deletion or K417N, R190S or K417T, T95I or R346K can be detected respectively.
Insights into the Binding of Receptor-Binding Domain (RBD) of SARS-CoV-2 Wild Type and B.1.620 Variant with hACE2 Using Molecular Docking and Simulation Approaches.
Introduction: This variant harbors E484K, N501Y, and P681H mutations in the spike protein, while many other new mutations accompany these mutations, including R346K, Y144T, Y145S, and 146N insertion.
Characterizing SARS-CoV-2 mutations in the United States.
SARS_CoV_2 mutation literature information.
PMID: 
2021
bioRxiv
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