Abstract: We explored the R346K substitution, prevalent in 42% of Omicron variants, known to be associated with immune escape by monoclonal antibodies.
Introduction: We also show the high prevalence of the R346K mutation as well as the emergence of different haplotypes during this period.
Result: Figure 3 shows the most frequent amino acid substitutions in the RBD (G339D, R346K, K417N, S371L, S373P, S375F, N440K, Q498R, and N501Y).
Result: Interestingly, samples with R346K in Mexico City clustered in a monophyletic br
Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants.
Introduction: More recently, the BA.2 and BA.1.1 sublines see continued expansion within Europe, the former of which lacks certain sequence variances in the Spike-Gene (notably del-HV69-70) and the latter featuring an additional one (R346K), both of which have been shown to affect antibody efficacy.
Evasion of vaccine-induced humoral immunity by emerging sub-variants of SARS-CoV-2.
Abstract: Results: Beta+R346K, which was identified in the Philippines in August 2021, exhibited the highest vaccine resistance among the tested mutants.
Introduction: Beta+R346K and Mu+K417N share the same haplotype with R346K, K417N, E484K and N501Y mutations in the receptor-binding domain (RBD) in the spike protein, as shown in Figure 2.
Introduction: In June, another variant harboring E484K and R346K was found in Angola with low neutralization titer against mRNA1273 vaccinated serum.
Introduction: To answer the question of whether immunity escape against existing vaccines or prior infe
R346K Mutation in the Mu Variant of SARS-CoV-2 Alters the Interactions with Monoclonal Antibodies from Class 2: A Free Energy Perturbation Study.
Discussion: The presented data provides new insight into the neutralization potential and cros
Discussion: The serum samples of hamster infected with Omicron (R346K) showed poor neutralization against other VOCs tested like Alpha, Beta and Delta variants.
Discussion: We found no evidence that Omicron (R346K) produce less severe lung disease or more predilection to upper respiratory tract in comparison to lung as reported earlier.
Discussion: We observed limited body weight gain, viral replication in the upper and lower respiratory tract and interstitial pneumonia in Syrian hamsters following infection with the Omicron (R346K) variant.
Discussion: We observed moderate to severe changes in the lungs of hamsters infected with Omicron (R346K).
Antigenicity comparison of SARS-CoV-2 Omicron sublineages with other variants contained multiple mutations in RBD.
Result: In this study, we used Omicron BA.1.1, which has an additional R346K mutation along with a constellation of mutations in S (compared to past VOC, c.f.
Genetic differentiation and diversity of SARS-CoV-2 omicron variant in Its early outbreak.
Abstract: Three of them are on the S protein, including S_A701V, S_L1081V, and S_R346K, which belong to the receptor-binding domain (RBD).
Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Result: Among the mutations in RBD, R346K, N440K, G446V, N450K, V483F, E484K, E484Q, F490S and S494P also showed change in ACE2 binding to the extent of 75% to 90%.
Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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