Result: Additionally, SNV signatures of previously characterized Brazilian genomes were found in most samples, such as G28881A and G28882A (98.6%; resulting in R203K change in N), G28883C (98.6%; resulting in G204R change in N), T27299C (91.6%; resulting in I33T change in ORF6), and T29148C (90.1%; resulting in I292T change in N).
BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.
PMID: 32904401
2020
Sustainable cities and society
Result: 8 ), and there were 5 variable sites with non-synonymous substitutions frequency over 20, including a trinucleotide substitution which led to two consecutive aa substitutions of R203K and G204R (Table 2).
Result: The two main types were the reference type (2561 strains) and the mutant type of N-R203K_G204R (494 strains).
Table: R203K
Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America.
PMID: 32950697
2020
Infection, genetics and evolution
Conclusion: Amino acid changes were found in the S and N proteins of SARS-CoV-2 circulating in South America, the most frequent being D614G in S and R203K-G204R and I292T in N.
Result: <
Result: In the N protein, five amino acid substitutions were found; the most frequent being R203K and G204R in 13.95% (6/43) of the sequences.
Result: Non-synonymous substitutions R203K and G204R, which are the hallmarks of the B.1.1 lineage, were the most frequent in the N protein of South American sequences.
A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individual.
PMID: 32967693
2020
Journal of translational medicine
Result: Interestingly, SARS-CoV2-UNIBS-GZ69 consensus differed from the early SARS-CoV-2-UNIBS-AP66 variant in 9 positions (C2939T; C3828T; G21784T; T21846C; T24631C; G28881A; G28882A; G28883C; G29810T) and these genetic variations have led to 4 non-synonymous substitutions in the ORF1ab (P892S, S1188L), in the S protein (K74N, I95T) and in the N protein (R203K, PMID: 32972934
2020
Microbiology resource announcements
Introduction: Compared with hCoV-19/Wuhan/WIV04/2019, for strain BCSIR-NILMRC-006, we found eight mutations, including NSP2_G339S, N_R203K, N_G204R, NSP3_Q172R, Spike_D614G, NSP2_I120F, NSP12_P323L, and NSP2_V480I.
Introduction: In BCSIR-NILMRC-008, the genome mutations Spike_D614G, N_R203K, N_G204R, NSP2_
Non-synonymous mutations of SARS-CoV-2 leads epitope loss and segregates its variants.
Discussion: R203K and G204R in nucleocapsid protein are found in SARS-CoV-2 of three Indian patients who traveled from Italy in April 2020.
Discussion: SARS-CoV-2 genome sequences available at the public database of the Global Initiative on Sharing All Influenza Data (GISAID) till 02-10-2020 classifies the variants into several clades like (i) L-original lineage, (ii) G-variant of spike protein causing D614S mutation, (iii) S- variant ORF8 responsible for L84S mutation, (iv) V- variant of the ORF3a coding protein N3S responsible for G251V mutation, (v) GH- a G derivative characterized by ORF3a: PMID: 33093050
2020
Microbiology resource announcements
Introduction: Four amino acid substitutions (ORF1b-P314L, S-D614G, N-R203K, and N-G204R) unique to clade GR (both lineages B.1.1 and B.1.1.28) were seen in all our sequences in this clade.
Table: R203K
New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release.
Abstract: Notable expanding mutations include R203K and G204R of the nucleocapsid (N) protein inter-domain linker region and G251V of the viroporin encoded by ORF3a between March and April.
Figure: A comparison of the R203K mutant and reference viral strain with a delta score revealed that the mutation increased disorder.
Discussion: The R203K and G204R mutations spanned regions of high disorder and high binding ability.
Discussion: The coordinated rates of increase of the R203K and G204R mutations indicated mutations did not occur randomly.
SARS-CoV-2 spread across the Colombian-Venezuelan border.
PMID: 33157300
2020
Infection, genetics and evolution
Abstract: Additionally, three mutations (R203K/G204R substitution) were present in the nucleocapsid (N) gene of one Venezuelan genome.
Result: Additionally, we identified three substitutions in the nucleocapsid (N) gene of VEN-89312 changing GGG-to-AAC at positions 28,616-28,618 resulting R203K/G204R substitutions according to the whole-genome position after removing the 5'UTR.
Result: These R203K/G204R substitutions, which have been reported previously in other South American genomes, were absent from the two other Venezuelan genomes we sequenced.
Genomic exploration light on multiple origin with potential parsimony-informative sites of the severe acute respiratory syndrome coronavirus 2 in Bangladesh.
Abstract: Genome-wide annotations revealed 256 mutations, of which 10 were novel (NSP3, RdRp, Spike) in Bangladeshi strains where I120F(NSP2), P323L(RdRp), D614G (Spike), R203K, G204R(N) are the most prominent.
SARS_CoV_2 mutation literature information.
PMID: 
2020
bioRxiv
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