Discussion: Many other missense and synonymous mutations found in respective proteins of Bangladeshi virus populations such as ORF1ab/nsp12_P323L, NS3_Q57H, NS8_R52I, N_S194L, N_R203K, and N_G204R, which are also common worldwide.
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.
Result: Furthermore, various amino acid mutations were also found in the other proteins of virus samples, including on NSP2 (A205V, V247A, T256I, Q321K), NSP3 (P679S, T1022I, A1179V, T1198K, F1354C, P1665L), NSP4 (A231V), NSP5 (K12R, M49I, P184S), NSP6 ( Table: R203K
Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan.
Result: Among the missense mutations, four were in the spike protein (W152L, E484K, D614G, and G769V), four were in ORF1ab (T4692I, N6301S, L6337M, and I6525T), one was in the membrane protein (F28L), and four were in the nucleocapsid protein (S187L, R203K, G204R, and Q418H).
Table: R203K
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Table: R203K
Structural phylogenetic analysis reveals lineage-specific RNA repetitive structural motifs in all coronaviruses and associated variations in SARS-CoV-2.
Result: Curiously, deletion of the RGTSPA sequence in N protein is exclusively found in Cluster B (Table 2), and the R203K-G204R variations are highly constrained in Cluster B (Table 2) and E (Supplementary Table S3).
Result: Several non-synonymous variations are found differential between cluster A and B, for example, C14408U, A23403G, and G28881A-G28882A-G28883C resulting in Nsp12 P323L, S protein D614G, and N protein R203K-G204R, were found differ, respectively (Table 2).
Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.
PMID: 34147651
2021
Infection, genetics and evolution
Abstract: Among the 7 highly recurring (percentage frequency>=10%) mutations (Nsp2:T85I, Nsp6:L37F, Nsp12:P323L, Spike:D614G, ORF3a:Q57H, N protein:R203K and N protein:G204R), N protein:R203K and N protein: G204R are co-occurring (dependent) mutations.
Abstract: Further, the occurrence of ORF3a: PMID: 34157472
2021
Computers in biology and medicine
Result: We have also noticed few other shared variations like R203K and G204R in nucleocapsid protein among the viral strains from Saudi Arabia and Russia, and the S166A variation in the viral strains from Saudi and India.
Table: R203K
High-precision and cost-efficient sequencing for real-time COVID-19 surveillance.
Result: Ten of the 25 sequences shared additional mutations of R203K and G204R in the N (nucleocapsid) protein (skyblue circle in.
Table: R203K
Discussion: In addition to the G clade's other common mutation, NSP12-P323L, frequent mutations we observed include N-S194L, N-R203K, N-G204R, NSP2-T85I, and ORF3a-Q57H.
Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh.
Result: Moreover, several mutations were found that persisted, (I120F, T412I, L37F, P323L, G204R, R203K, and D614G) for more than 6 weeks (Table 1 and.
Discussion: On the other hand, the temporal analysis of mutation accumulation also showed mutations (P323L, I120F, D614G, R203K, G204R) that persist over a longer period of time.
Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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