Result: In addition, several aa substitutions can be seen in the NSP3 (S370L, K977Q), NSP12 (P323L), and NSP13 (E341D), NS3 (S253P), NS8 (E92K), N-protein (P80R, R203K, G204R).
Result: Moreover, the UK-VOC contains several aa substitutions in other genomic regions, including NSP3: T183I, A890D, I1412T, NSP12:
SARS-CoV-2 mutations: the biological trackway towards viral fitness.
Introduction: Cluster I includes 3037C>T; NSP3:F106F (non-structural protein3:F106F) and 14408C>T; RdRp:P323L, cluster II includes 3037C>T, 14408C>T and 23403A>G; S:D614G, cluster III includes 14408C>T, cluster IV includes 3037C>T, 14408C>T, 23403A>G, 28881G>A; N:R
Table: R203K
Assessment of basic reproduction number (R0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh.
PMID: 33930563
2021
Infection, genetics and evolution
Abstract: Alternatively, I120F in NSP2 protein, R203K and G204R in nucleocapsid protein, and P323L in RdRp were more recurrent.
Result: Besides all other essential protein, another most abundant changes were observed in the N protein (R203K, G204R), which is mainly targeted in the diagnostics purposes.
Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.
PMID: 33966351
2021
Transboundary and emerging diseases
Result: Interestingly, three sequential SNP sites (28881-3.GGG>ACA) were fixed in 22% (207/951) of the European SARS-CoV-2 isolates, resulting in a synonymous mutation and two missense mutations (Arg 203 Lys and Gly 204 Arg) (Table 1).
Table: Arg203Lys
Genomic epidemiology of SARS-CoV-2 in Esteio, Rio Grande do Sul, Brazil.
Abstract: RESULTS: We provided a comprehensive view of mutations from a representative sampling from May to October 2020, highlighting two frequent mutations in spike glycoprotein (D614G and V1176F), an emergent mutation (E484K) in spike Receptor Binding Domain (RBD) characteristic of the B.1.351 and P.1 lineages, and the adjacent replacement of 2 amino acids in Nucleocapsid phosphoprotein (R203K and G204R).
Conclusion: Our results provide a comprehensive view of SARS-CoV-2 mutations from a time- and age-representative sample from May to October 2020, highlighting two frequent mutations in spike glycoprotein
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.
PMID: 34029587
2021
The Journal of biological chemistry
Discussion: Interestingly, the only variant in N protein is R203K;G204R in the B.1.17 strain and T205I in B.1.351 strain, suggesting the RGT sequence is an important regulatory site.
SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains.
Discussion: The European strain carries additional mutations, notably the hotspot mutations R203K and G204R, that cluster in a serine-rich linker region at the RdRp.
E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.
PMID: 34044192
2021
Infection, genetics and evolution
Result: S:D614G, N:R203K, Discussion: The occurrence of simultaneous mutations as N:R203K and N:G204R is already known in the SARS-CoV-2 literature.
Discussion: The presence of spike S:D614G, N:R203K, N:G204R, and Nsp12:P323L in all sequenced E484 mutated samples, reaching three different lineages, might suggest that these lineages show increased viral replication.
Identification of E484K and other novel SARS-COV-2 variants from the Kingdom of Bahrain.
Result: Four mutations were located within nonstructural proteins (Nsp3: T1246I, Nsp3: T1250I, Nsp5: G3278S, Nsp12: P4715L), three in the nucleocapsid (S2F, R203K, G204R), and two affecting the spike protein (D6
Discussion: Three variants were located within the N-protein coding gene, two of these polymorphisms refer to amino acid changes (R203K and G204R), which have been associated earlier to increased fitness and adaptation.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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