Abstract: In addition, a retention of Q57H (B.1.X), R203K/G204R (B.1.1.X), T85I (B.1.2-B.
Result: Other major mutations noted are Q57H (26.5%), R203K/G204R (33%), G15S (12%), I120F (11.5%), and T85I (14%).
Result: These are Q57H (nucleotide 25,563, G to T) in ORF3a, the R203K + G204R combination (nucleotide 28,881, GGG to AAC) in nucleocapsid, and T85I (nucleotide 1,059, C to T) in ORF1a.
Ongoing global and regional adaptive evolution of SARS-CoV-2.
Result: 3D and SI Appendix, Table S3; see Brief Methods), in which the central hubs are D614G in the spike (<
Figure: Black nodes correspond to key amino acid substitutions S L18F, S A222V, S S477N, S N501Y, S D614G, S P681H, S T716I, N R203K, and N G204R.
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Result: The N_R203K mutation was reported at 24.24%, 75.88%, 47.90%, 53.51%, 15.08% and 76.41% in SARS-CoV-2 genome sequences isolated from Africa, Asia, Australia, Europe, North America and South America, respectively.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Result: After the importation of B.1.1 lineages characterized by N:R203K and N:G204R mutations, community transmission massively occurred and gave rise to B.1.1.28 (S:V1176F) and B.1.1.33 lineages (ORF6:I33T and N:I292T), widely distributed in Brazilian regions along the first year of the pandemic.
SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.
PMID: 34425504
2021
Diagnostic microbiology and infectious disease
Conclusion: In addition, both sequences presented the R203K and G204R aminoacid change in the nucleocapsid (N) protein.
Table: R203K
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
Result: Consistent with this study, we identified R203K, G204R, S194L, and M234I in the nucleocapsid protein as shared mutations between Columbia and Rock Hill WWTP influents in January 2021 (Supplementary Table S3).
Result: In particular, R203K and G204R both had a mutation rate of 0.22, indicating that they were present in 22% of all sequences as of December 2020.
Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally.
Result: In the N protein, the highest mutation was R203K (61.3%).
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in Wastewater.
PMID: 34445204
2021
International journal of molecular sciences
Result: Although these mutations are located on the linker region (LKR) of the nucleocapsid phosphoprotein, which spans from position 175-254aa, only R203K belongs to the LKR's crucial Ser/Arg (SR)-rich motif that contains putative phosphorylation sites.
Result: Five well-characterized missense mutations, D614G (23403A>G)-S gene, Q57H (25563G>T)-ORF3a gene, P323L (14408C>T):ORF1ab/RdRP gene, R203K (28881G>A):N gene, and
Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.
Result: Beside these, two of the high frequency (86%) SNVs (R203K and G204R) occurred in COVID-19 diagnostic RT-PCR target and B-Cell predicted epitope regions, of which the later was predicted to cause altered function of the Table: R203K
Discussion: The second most frequent mutation in our analysis was a tri-nucleotide change resulting in two amino acid changes which are R203K and G204R in N protein.
Discussion: This finding is similar with other studies those reported R203K and G204R destabilizes N protein structure but may enhance interaction with SARS-CoV-2 Envelop protein that may promote viral release.
SARS_CoV_2 mutation literature information.
PMID: 
2021
mBio
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