literature

SARS_CoV_2 mutation literature information.

A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations.

PMID: 35222380 2022 Frontiers in immunology

Method: Simultaneously, some mutations such as R203K and G204R are too noted in the Omicron variant.

Worldwide SARS-CoV-2 haplotype distribution in early pandemic.

PMID: 35171928 2022 PloS one

Table: p.Arg203Lys

Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines.

PMID: 35215919 2022 Viruses

Result: These changes included, but were not limited to, D614G in Spike; R203K and G204K in N; and an out-of-frame deletion of five nucleotides in ORF7A, leading to its premature truncation.

RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant.

PMID: 35293849 2022 Emerging microbes & infections

Method: Similarly, R203K/

Figure: (E) The specific differences in the R203M, R203K/G204R and T205I mutations in the N gene sequence.

Figure: Numbers 1-4: the amplified curve of the R203M, R203K/G204R, T205I mutant-containing template and wild template using the conserved primer set.

Impaired detection of omicron by SARS-CoV-2 rapid antigen tests.

PMID: 35187580 2022 Medical microbiology and immunology

Introduction: P13L, DEL31/33, R203K and G204R, and the additional mutation S413R is present in BA.2 (Suppl.

Result: The expanded omicron isolate (GISAID 7808190; BA.1 sublineage) carries the expected P13L, del31/33, R203K and G204R mutations.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; ORF8: Q27stop, R52I, Y73C, S84L<

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.

PMID: 34541432 2021 Pathogens & immunity

Abstract: In this study, we examined the adjacent amino acid polymorphisms in the nucleocapsid (R203K/G204R) of SARS-CoV-2 that arose on the background of the spike D614G change and describe how strains harboring these changes became dominant circulating strains globally.

Introduction: Here we examined a variant of SARS-CoV-2 that emerged within the subset of sequences harboring the D614G variant and contains 3 adjacent nucleotide changes spanning 2 residues of the nucleocapsid protein (R203K/G204R; B.1.1 lineage), which has resulted in a novel sub-genomic RNA transcript.

Method: The Dot-bracket folding notations were obtained for each of the

PMID: 34445204 2021 International journal of molecular sciences

Result: Although these mutations are located on the linker region (LKR) of the nucleocapsid phosphoprotein, which spans from position 175-254aa, only R203K belongs to the LKR's crucial Ser/Arg (SR)-rich motif that contains putative phosphorylation sites.

Result: Five well-characterized missense mutations, D614G (23403A>G)-S gene, Q57H (25563G>T)-ORF3a gene, P323L (14408C>T):ORF1ab/RdRP gene, R203K (28881G>A):N gene, and

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

PMID: 34448936 2021 Archives of virology

Table: R203K

Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and high-frequency mutation N501Y in different levels of control measures.

PMID: 34493762 2021 Scientific reports

Method: For instance, if 1 week presented 30% of genomes with the mutation R203K, and the number of cases on Monday of that week was 100.

Method: In the case of MF mutation R203K, R203, and N501, we multiply the relative frequencies of the genomes with the state of interest (R203K, R203 or N501) in a determined week by the number of cases in the day.

Result: This explains why this mutation did not increases its frequency steadily and can be an evidence of constant competition between MFR203K and not-MFR203K.

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