literature

SARS_CoV_2 mutation literature information.

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.

PMID: 33170902 2020 PloS one

Result: For the four other hotspot mutations were distributed in ORF3a (Q57H and G251V) and nucleocapsid phosphoprotein (R203K and G204R).

Result: SARS-CoV-2 genomes also harbored three co-occurrent mutations R203K, R203R and G204R in the N protein and were present in all continents except Africa and Asia (besides Taiwan).

Result: The first subcluster SCB3 harbored strain sharing two mutation R203K (N) and G204R (N) harboring largely strains from Europe and some strains from North Africa (Franc

Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations.

PMID: 33184173 2020 Proc Natl Acad Sci U S A

Result: In addition to the three type VI signature SNVs, five additional subtype SNVs with variation frequencies of >0.1 included C1059T (nsp2, T265I), G25563T (ORF3a, Q57H), G28881A (N, R203K), G28882A (N, R203K), and G28883C (N, G204R).

Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.

PMID: 33201914 2020 PloS one

Table: R203K

Discussion: Interestingly, these three variants always occurred together, and sometimes they were accompanied by a synonymous mutation C241T (in 39 genomes) or multiple nucleotide substitutions GGG28881..28883AAC (N: R203K, G204R; in 33 genomes), suggesting linkage of mutations among these strains.

Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.

PMID: 33329480 2020 Frontiers in microbiology

Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A (R203K, N gene), 28882 G > A (R203R, N gene), 28883 G > C (G204R, N gene), and

Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models.

PMID: 33357233 2020 Genome biology

Result: The impact of this variation, corresponding to a double mutation at the protein level (Arg203Lys and Gly204Arg), results in an additional positively charged site, and possibly, it increases local rigidity with the subtraction of Gly204.

Result: The wavelet analysis simultaneously displays the location, frequency, and mutational density at different scales and identified a cluster of moderately frequent mutations involving 14 amino acids in a serine/arginine-rich motif of N (Ser180Ile, Ser183Tyr, Ser188Leu, Ser190Asn, Ser193Ile, Ser194Leu, Arg195Lys, Ser197Leu, Ser202Asn

The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.

PMID: 33496683 2020 JMIR bioinformatics and biotechnology

8Discussion: It was not surprising to observe the triple site mutation 28881-28883 GGG>AAC (

Discussion: Few strains from Europe and North America since February 2020 have shown the emergence of mutations like 3037C>T (F106F, NSP3), 23403A>G (D614G), and 28881-28883GGG>AAC (R203K and G204R, N) in the SARS-CoV-2 genome harboring the 14408C>T (P323L) mutation within the RdRP gene, suggesting a probable association or coexistence of 14408C>T (P323L) and the emerging higher number of novel point mutations compared to viral genomes from Asia.

SARS-CoV-2 Genomes From Oklahoma, United States.

PMID: 33613621 2020 Frontiers in genetics

Abstract: Previously reported mutations including D614G in S gene, P4715L in ORF1ab, S194L, R203K, and G204R in N gene were identified in the genomes sequenced in this study.

Introduction: N gene mutations R203K and G204R are believed to increase viral fitness, survival and adaptation to humans.

Introduction: SNPs in the genome that result in commonly reported non-synonymous mutations such as P4715L in ORF1ab, D614G in S gene,

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