literature

SARS_CoV_2 mutation literature information.

Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?

PMID: 34206453 2021 Viruses

Introduction: Five mutations are located within NTD (L18F, T20N, P26S, D138Y, R190S), three in RBD (K417T, E484K, N501Y), two in the C-terminal domain of S1 and near the furin cleavage site (D614G, H655Y), and one in S2 (T1027I) (Figure 3).

Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil.

PMID: 34241897 2021 Journal of medical virology

Result: P.1 defining mutations related to each genomic region were the following: ORF1ab: S1188L, K1795Q, E5665D; spike: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I; Orf8: E92K; and nucleocapsid: P80.

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.

PMID: 34351895 2021 PLoS computational biology

Result: P.1 variant includes the mutations L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I.

Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.

PMID: 34363852 2021 Virus research

Table: R190S

Discussion: Of the 10 new amino acid mutations in the spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) compared to its immediate ancestor (B.1.1.28), molecular selection analyses found evidence that 8 of these 10 mutations are under diversifying positive selection.

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.

PMID: 33664494 2021 Nature medicine

Method: Amino acid substitutions for B.1.1.7, P.1 (Brazilian lineage: L18F, T20N,

Result: Given these results with viruses encoding E484K mutations, we performed separate studies with human convalescent serum (n =10) and a chimeric SARS-CoV-2 WA1/2020 strain encoding a Brazilian variant spike gene (Wash BR-B.1.1.248; L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F [Extended Data Fig 5a]).

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Table: R190S

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: P.1: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F.

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Table: R190S

An Autochthonous Outbreak of the SARS-CoV-2 P.1 Variant of Concern in Southern Italy, April 2021.

PMID: 34449757 2021 Tropical medicine and infectious disease

Introduction: These amino acid changes are L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F.

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