Result: Compared to the Wuhan sequence, P.1 contains the following mutations: L18F, T20N, P26S, D138Y, and R190S in the NTD; K417T, E484K, and N501Y in the RBD; D614G and H655Y at the C terminus of S1; and T1027I and V1176F in S2.
Result: Of note, two of the NTD changes in P.1 introduce N-linked glycosylation sequons T20N (residues TRT to NRT) and R190S (residues NLR to NLS; Figure 1E).
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.
Introduction: Lineage P.1 contains 10 lineage-defining amino acid mutations in the virus spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I) compared with its immediate ancestor (B.1.1.28).
A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil.
Introduction: The VOC P.1, first described in January 2021, displayed an unusual number of lineage-defining mutations in the S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) and its emergence was associated with a second COVID-19 epidemic wave in the Amazonas state.
Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.
Result: The BR-VOC is highly mutated in the S-gene resulting in 12 aa substitutions in the S-protein including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.
E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.
PMID: 34044192
2021
Infection, genetics and evolution
Result: Regarding the lineage-defining mutations from P.1 lineages, 14 of a total of 19 genomes from the Amazonas monophyletic group present the spike mutations L18F, T20N, P26S, D138Y, and R190S.
Result: Three of them (189, 191, and 564) are near residues presenting known nonsynonymous mutations in the E484K mutated genomes, as S:R190S and S:F565L.
Table: R190S
SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection.
PMID: 34109031
2021
Annals of medicine and surgery (2012)
Introduction: These mutations are L18F, T20N, P26S, D138Y, R190S, D614G H655Y, T1027I, and V1176F.
Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.
Method: The variant P.1 (GISAID: EPI_ISL_792681) was constructed with 12 mutations including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Frontiers in public health
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