Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.
Result: Fifteen substitutions (10 in the spike protein: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I) are P.1 lineage-defining mutations (Figure 1B and Table 2).
Discussion: The VOC P.1 carries three deletions, four synonymous substitutions, a four base-pair nucleotide insertion, and at least 17 other lineage-defining replacements, including 10 missense mutations in the spike protein (L18F, T20N, P26S, D138Y,
Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM Refiner.
Result: We classified the sequences found from the NTD amplicon as matching reference sequence, lineage B.1.1.7 (Alpha) with '203-208Del 429-431Del' or lineage P.1 (Gamma) with '412T(D138Y) 570T(R190S)' (Supplementary 10).
Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.
Method: We used the following amino acids replacements and deletions in Spike for each lineage-based COG-UK defined changes for each lineage; Beta (B1.351; L18F, D80A, D215G, R246L, K417N, E484K, N501Y, A701V), Gamma (P.1; L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y H655Y, T1027I), Alpha (B.1.1.7; Delta69-70, D144, PMID: 34536797
2021
Virology
Result: Few NTD mutations, namely T20N, P26S, D138Y, and R190S, likely contributed to the increase in ACE2 binding, with ~2, ~1.6, ~1.3 and ~1.8- fold increase compared to D614G, respectively.
Result: In the P.1 Spike we observed mutations in the NTD that decreased recognition (P26S, D138Y, and R190S).
Result: Our results show that all the NTD mutations, namely L18F, T20N, P26S, D138Y and R190S, attenuated the binding of naive-vaccinated plasma Abs.
The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.
PMID: 34547629
2021
Biochemical and biophysical research communications
Table: R190S
Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Pathogens (Basel, Switzerland)
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