Linked nosocomial COVID-19 outbreak in three facilities for people with intellectual and developmental disabilities due to SARS-CoV-2 variant B.1.1.519 with spike mutation T478K in the Netherlands.
Abstract: Recently, SARS-CoV-2 delta variant prevails over different countries that have 3 unique mutation sites: E156del/R158G in the N-terminal domain and T478K in a crucial
Introduction: The comparison of SARS-CoV-2 delta variant with other variants revealed 3 unique mutation sites, E156del, R158G, and T478K, which were indicated by red letter (Table 1 and.
Method: The three unique mutation sites, E156del, R158G, and T478K in the SARS-CoV-2 delta variant must be investigated if a recent outbreak of COVID-19 depends on the mutation sites in the S gene of SARS-CoV-2 delta variant.
Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.
Abstract: Furthermore, five key mutations (T95I, A222V, G142D, R158G, and K417N) were significantly more prevalent in the Delta Plus than in the Delta variant.
Introduction: To assess how Delta Plus was evolving from Delta, we determined the prevalence of six key mutations (T95I,
Introduction: To assess if mutations change sidechain conformation, we generated mutations W258A, G142D and R158G using Prime software of Schrodinger Suite (Schrodinger LLC, NY).
Introduction: We also included G142D and R158G since these mutations occurred at high prevalence (69-100 %).
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
Table: R158G
Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.
The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.
PMID: 34547629
2021
Biochemical and biophysical research communications
Table: R158G
Evaluation of the clinical and analytical performance of the Seegene allplex SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI).
SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response.
PMID: 34639178
2021
International journal of molecular sciences
Discussion: In the Delta variant, mutations T19R, E156-, F157- and R158G severely affect NTD directed Abs, due to the adoption of an alpha-helical conformation, instead of the original beta-strand.
Spike protein evolution in the SARS-CoV-2 Delta variant of concern: a case series from Northern Lombardy.
Method: SARS-CoV-2 pseudotyped lentiviruses were prepared by co-transfecting the HEK293T cell line with either the SARS-CoV-2 ancestral variant spike (D614G), the Beta spike (L18F, D80A, D215G, K417N, E484K, N501Y, D614G, A701V, 242-244 del) or the Delta spike (T19R, R158G L452R, T478K, D614G, P681R, D950N, 156-157 del) plasmids in co
SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Immune network
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