A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.
PMID: 34806033
2021
Current research in structural biology
Introduction: Recently, a rapidly transmitting variant emerged in India, namely- B.1.617.2 (Delta) with unique RBD mutations E484Q and L452R, two deletions (E156del and
Result: Another consecutive substitution, R158G also perturbed the formation of 5 hydrogen bonds in the variant.
Result: Similarly, the recent B.1.617.2 lineage possess 4 NTD mutation combination (T19R, E156del, F157del, and R158G).
Result: Within the NTD, five prominent variant stretches were observed, with Y144 deletion, G142D, E156-F157 deletion, and R158G segment as the largest contiguous patch.
Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.
Introduction: The Delta (B.1.617.2) variant encodes an S protein with ten mutations (T19R, G142D, del 156, del 157, R158G, L452R, T478K, D614G, P681R, and D950N), two of which are in the RBD (L452R and T478K).
SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.
Introduction: The three substitutions (T19R, G142D, and R158G) and two deletions (DeltaE156, DeltaF157) in NTD occur in the NTD antigenic supersite spanning between residues 14-20, 140-158, and 245-264.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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