literature

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda.

PMID: 34230931 2022 bioRxiv

Abstract: The A.23 viral lineage, characterized by three spike mutations F157L, V367F and Q613H, was first identified in COVID-19 cases from a Ugandan prison in July 2020, and then was identified in the general population with additional spike mutations (R102I, L141F, E484K and P681R) to comprise lineage A.23.1 by September 2020, with this virus being designated a variant of interest (VOI) in Africa and with subsequent spread to 26 other countries.

Introduction: This lineage then spilled into the general population adding additional spike mutations (R102I,

PMID: 32954666 2021 Transboundary and emerging diseases

Table: R102I

Identification of E484K and other novel SARS-COV-2 variants from the Kingdom of Bahrain.

PMID: 34058304 2021 Microbial pathogenesis

Result: H49Y[blue], W64L, A67S, G75S(77), T76I(77)[magenta], R78 M, R102I[blue], V127F, L141del[sky], G142del[sky], V143del[sky], Y144del(143)[sky], E154G, E156D, M177I, S255F(257)[blue], I358V[yellow], L452 M[yellow], S459F[yellow], E484Q[yellow], E484K[yellow

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: R102I

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

PMID: 34373458 2021 Nature communications

Table: R102I

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: R102I