literature

SARS_CoV_2 mutation literature information.

Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.

PMID: 34801754 2022 Infection, genetics and evolution

Result: S17) reveals 14 mutations out of 64 total that appear to be consistently present (P681H, Q677H, Q675H, Q677P, S673T, N679K, P681R, Q675R, P681L, T676I, T678I, A684V, Q677R, and A672V).

Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France.

PMID: 34839413 2022 Virus genes

Abstract: At the end of 2020, an increasing incidence of spike substitutions Q677H/P was described in the USA, which involved six independent lineages.

Introduction: At the end of 2020, the incidence of variants carrying the Q677H, or Q677P substitutions in the spike increased, mainly in the USA, where the first sequences originate

Result: reported the emergence late 2020 of variants harbouring substitutions Q677H/P in the spike of viruses that were classified into sublineages of Nextstrain clades 20B and 20G as well as into Nextstrain clade 20A, and the Q677H substitution has been identified in the B.1.525 lineage first described in Nigeria and as a fast growing mutation in variants of concern.

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Table: Q677P/H

Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677.

PMID: 33594385 2021 medRxiv

Result: Although the Q677P position is outside the furin binding pocket, we speculate that the presence of a proline at this site may introduce a favorable kink that promotes the dynamic conformational changes necessary for cleavage at the S1/S2 junction, which is governed not only by furin-like activities, but also by trypsin-like proteases (e.g., TMPRSS2) and cathepsins.

Result: Broad-scale genomic surveillance efforts conducted by the New Mexico Department of Health (NM DOH) and the UNM HSC in December and January, 2021 revealed that 83 of 733 SARS-CoV-2 genomes sequenced in New Mexico between December 1st and January 19t

Result: In part due to deep sampling of the large outbreak, the Q677P virus amounted to 37.2% of all viral genomes sequenced from Dec 2020 samples collected in Louisiana (LSUHS submissions account for 481 of the 503, or 95.6% of Dec 2020 viral genome sequences available on GISAID for the state).

Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco.

PMID: 33688689 2021 medRxiv

Result: Moderately prevalent mutations were observed at spike position 681 (P681H, n=29 and P681R, n=1), which is within the furin recognition site, and at spike position 677, where two different amino acid substitutions were observed in this cohort (Q677H, n=21 and Q677P, n=10).

SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations.

PMID: 33804556 2021 Viruses

Result: Mutations at residue Q677 (either Q677H or Q677P) were found in several independent lineages spreading over the autumn of 2020 and into the winter of 2021 in the USA.

Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.

PMID: 34258664 2021 Archives of virology

Abstract: Here, we analyzed the frequency of Q677P/H and FCS point mutations in 1,144,793 human and 1042 animal spike protein sequences and from those of the emergent variants B.1.1.7, B.1.351, P.1, B.1.429 + B.1.427, and B.1.525, which were deposited in the database of the GISAID Initiative.

Abstract: The SARS-CoV-2 spike protein Q677P/H mutation and furin cleavage site (FCS) have been shown to affect cell tropism and viru

Introduction: Here, we analyzed the evolutionary patterns of Q677P/H and FCS amino acids residues (amino acid positions 680-689) from all animal and human variants and five major emergent variants for which whole-genome SARS-CoV-2 sequences had been deposited in the GISAID Initiative database since the start of the COVID-19 pandemic.

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Result: On the other hand, only 10 variants have destabilized the spike protein (e.g., E484K, K417 N, V1176F, E484Q, Q675P, G1167V, E553D, L5F, Y453F and Q675H) meanwhile, 18 variants (e.g., A262S, D080A, Q677P, N501T, A701V, Q677H, L452R, N501Y, D614G, P681R, L18F

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: Dual mutants containing D614G and other amino acid changes, including those under positive selection or observed in VOCs (L5F, L18F, S98F, W152L/C, E154K, L222V, and A262S in S1-NTD; N439K, L452Q/R, S477N, L478R/K, E484K/Q, N501Y, and A570D within S1-RBD; Q677H/P and P681H/R in S1-CTD; T716I,

The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.

PMID: 34940505 2021 Journal of developmental biology

Introduction: In some strains, it bears Q677H, whereas in others it is Q677P.

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