literature

SARS_CoV_2 mutation literature information.

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.

PMID: 34074255 2021 BMC medical genomics

Abstract: About 94% (16/17) of the virus samples showed D614G on spike protein and 56% of these (9/16) showed other various amino acid mutations on this protein, including L5F, V83L, V213A, W258R, Q677H, and N811I.

Result: The majority of the virus samples (16/17) possessed D614G substitution on spike protein and 56% of these (9/16) showed other amino acid su

Table: Q677H

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

PMID: 34103090 2021 European journal of medical research

Table: Q677H

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Result: In addition, mutations more than 3 were found, such as L54F (40 mutations), R78M (15 mutations), V367F (5 mutations), A829T (10 mutations), H1083Q (4 mutations), T791I (12 mutations), Q677H (4 mutations), E583D (15 mutations), T572I (10 mutations), and L8V (4 mutations).

Table: Q677H

Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants.

PMID: 34207378 2021 Viruses

Introduction: Like H665Y, the Q677H mutation is located near the furin cleavage site and may be involved in rapid virus replication, in addition to RBD-ACE2R binding.

Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.

PMID: 34258664 2021 Archives of virology

Abstract: Spike Q677P was detected only once in variant, B.1.1.7, whereas Q677H was detected in all variants, i.e., B.1.1.7 (n = 1938), B.1.351 (n = 28), P.1 (n = 9), B.1.429 + B.1.427 (n = 132), and B.1.525 (n = 1584).

Abstract: Here, we analyzed the frequency of Q677P/H and FCS point mutations in 1,144,793 human and 1042 animal spike protein sequences and from those of the emergent variants B.1.1.7, B.1.351, P.1, B.1.429 + B.1.427, and B.1.525, which were deposited in the database of the GISAID Initiative.

Abstract: Taken together, our results show that Q677H and FCS point mutations are prevalent and may have various biological effects on the circulating variants.