literature

SARS_CoV_2 mutation literature information.

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Result: In addition, mutations more than 3 were found, such as L54F (40 mutations), R78M (15 mutations), V367F (5 mutations), A829T (10 mutations), H1083Q (4 mutations), T791I (12 mutations), Q677H (4 mutations), E583D (15 mutations), T572I (10 mutations), and L8V (4 mutations).

Table: Q677H

Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants.

PMID: 34207378 2021 Viruses

Introduction: Like H665Y, the Q677H mutation is located near the furin cleavage site and may be involved in rapid virus replication, in addition to RBD-ACE2R binding.

Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.

PMID: 34258664 2021 Archives of virology

Abstract: Spike Q677P was detected only once in variant, B.1.1.7, whereas Q677H was detected in all variants, i.e., B.1.1.7 (n = 1938), B.1.351 (n = 28), P.1 (n = 9), B.1.429 + B.1.427 (n = 132), and B.1.525 (n = 1584).

Abstract: Here, we analyzed the frequency of Q677P/H and FCS point mutations in 1,144,793 human and 1042 animal spike protein sequences and from those of the emergent variants B.1.1.7, B.1.351, P.1, B.1.429 + B.1.427, and B.1.525, which were deposited in the database of the GISAID Initiative.

Abstract: Taken together, our results show that Q677H and FCS point mutations are prevalent and may have various biological effects on the circulating variants.

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Table: Q677H

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

PMID: 34307771 2021 Virusdisease

Table: Q677H

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

PMID: 34373458 2021 Nature communications

Table: Q677H

The Emergence and Spread of Novel SARS-CoV-2 Variants.

PMID: 34409009 2021 Frontiers in public health

Result: The mutation Q677H and N501Y in S protein have been proved to have higher affinity binding to ACE2.

Result: The mutations Q52R, E484K, Q677H, and F888 are in S protein.

Table: Q677H

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Table: Q677H

Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutations.

PMID: 34458642 2021 Heliyon

Figure: Mutated amino acid positions shown in the human ACE2 receptor bound structure (PDB ID: 6acj) of SARS-CoV-2 spike protein (except L5F, S13I, Q14H, G75V, T76I, Y145del, H146Y, Q675 H/R, Q677H, N679K, I834V, R1185H and K1195N as the regions were not covered in the structure).

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: Q677H

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