Introduction: One of these is a substitution of a Q677H, which has now been reported in multiple lineages of circulating variants of SARS-CoV-2 in the US population as early as mid-August 2020.
Introduction: Relative to the deposited sequence on GISAID (EPI_ISL_678615), we identified two additional mutations within the spike protein at positions Q677H and R682W (Figure S1).
SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations.
5Result: The other two fast growing ""sibling"" mutations in VOC:Q677H (256 genomes) and Q675H (86 genomes):are present in the the proximity of the polybasic cleavage site (residues 682-685) at the S1/S2 boundary influencing
Abstract: Of concern are immune escape mutations acquired by the VOC: E484K, F490S, S494P (in the receptor binding motif of spike) and Q677H, Q675H (in the proximity of the polybasic cleavage site at the S1/S2 boundary).
Result: Mutations at residue Q677 (either Q677H or Q677P) were found in several independent lineages spreading over the autumn of 2020 and into the winter of 2021 in the USA.
Spike protein mutational landscape in India during the complete lockdown phase: Could Muller's ratchet be a future game-changer for COVID-19?
PMID: 33905891
2021
Infection, genetics and evolution
Result: In this ancestor 2 clade, several variants (L5F, T22I, L54F, G261S, T572I, E583D, Q677H, A706S, H1083Q) indicated their stability in the population via mutating further, giving rise to additional variants.
Genome sequencing of SARS-CoV-2 in a cohort of Egyptian patients revealed mutation hotspots that are related to clinical outcomes.
PMID: 33932525
2021
Biochimica et biophysica acta. Molecular basis of disease
Result: In the S gene encoding the spike glycoprotein, we observed missense mutations at 23,403 (D614G, n = 47), 23,480 (S640A, n = 6), and 23,593 (Q677H, n = 6), 8 frameshift deletions at 21,574 (V6fs), and 7 synonymous mutations at 23,731 (T723*).
Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage.
PMID: 33991677
2021
Clinical microbiology and infection
Abstract: RESULTS: We identified that SARS-CoV-2 genomes from four patients diagnosed in our institute harboured a new set of amino acid substitutions including L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V +- Q677H.
Result: Moreover, 21 genomes, one from our institute, the 8 ones from Mayotte, and 12 other genomes from France or Turkey were clustered and all harbored the spike Q677H substitution.
Result: These mutations include aa substitution N501Y, associated with aa substitutions L18F, L452R, PMID: 32954666
2021
Transboundary and emerging diseases
Table: Q677H
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics.
Discussion: The B1.525 variant harbors a Q677H mutation, the variant B1.1.7 reported in the United Kingdom carries A570D and P681H mutations, the P1 variant from Brazil shows the H655Y mutation, and the recently reported B.1.617 strain in India shows a P681R change.
An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.
Discussion: In addition, this study observed the presence of individual amino acid variants in the SARS-CoV-2 variants B.1.1.7 (S494P), B.1.525 (A67V, Q677H), B.1.526 (L5F, T95I, S477N), and P2 (V1176F) in the earlier samples.
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.
Abstract: About 94% (16/17) of the virus samples showed D614G on spike protein and 56% of these (9/16) showed other various amino acid mutations on this protein, including L5F, V83L, V213A, W258R, Q677H, and N811I.
Result: The majority of the virus samples (16/17) possessed D614G substitution on spike protein and 56% of these (9/16) showed other amino acid su
Table: Q677H
Discussion: L5F, V213A, W258R, Q677H, and K811I.
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
SARS_CoV_2 mutation literature information.
PMID: 
2021
Cell host & microbe
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