Introduction: The COH.20G/677H spike protein contains D614G, N501Y, and Q677H but lacks the mutations present in B.1.1.7 and B.1.351, suggesting an independent origin.
A Gapless, Unambiguous RNA Metagenome-Assembled Genome Sequence of a Unique SARS-CoV-2 Variant Encoding Spike S813I and ORF1a A859V Substitutions.
Abstract: However, three mutations are worth highlighting and future tracking: a synonymous mutation causing a rare spike S813I variation and two less frequent ones leading to an A41V variation in NSP3, encoded by ORF1a (ORF1a A895V), and a Q677H variation in the spike protein.
Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa.
Abstract: RESULT: A total of 553 MENA sequences were analyzed and the most frequent S gene mutations included: D614G = 435, Q677H = 8, and V6F = 5.
Result: The most frequent mutation detected in the whole S region was D614G (n = 435), followed by Q677H (n = 8), and V6F (n = 5).
Table: Q677H
Discussion: Other amino acid replacements that were found in the study included Q677H (found only in Egypt), and L5F found in three different countries (Oman, Egypt, and Morocco).
Discussion: The functional importance of Q677H replacement as not been determined yet d
Variant analysis of SARS-CoV-2 genomes in the Middle East.
Abstract: Phylogenetic analyses revealed the independent evolution and spread of at least six disti
Discussion: Between August and November, 2020, seven independent lineages of SARS-CoV-2 with S:Q677H or S:Q677P mutations arose and gained in frequency.
Discussion: Furthermore, a newly designated, emergent PANGO lineage, B.1.525, carries S: Q677H in addition to several mutations seen in B.1.1.7 (501Y.V1), such as S: del 69-70 and S: del 144, and also, S: E484K.
Discussion: Given their relatively recent emergence, however, Q677P/H lineages may continue to rise as a percentage of total cases.
Isolation and genetic characterization of SARS-CoV-2 from Indian patients in a single family without H/O travel abroad.
Abstract: On comparison with Wuhan strain, 3 unique mutations were identified in nsp3 (A1812D), exonuclease (P1821S) of Orf1ab and spike protein (Q677H) regions, respectively.
Result: A1812D, P1821S and Q677H mutations, respectively, in nsp3, exoN of ORF1ab and spike protein were unique to IRSHA isolates.
Result: Eight mutations resulted in amino acid changes at positions 5700 (nsp3, A1812D), 1
Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco.
Result: Moderately prevalent mutations were observed at spike position 681 (P681H, n=29 and P681R, n=1), which is within the furin recognition site, and at spike position 677, where two different amino acid substitutions were observed in this cohort (Q677H, n=21 and Q677P, n=10).
A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.
PMID: 33705994
2021
Computers in biology and medicine
Table: Q677H
Coding-Complete Genome Sequences and Mutation Profiles of Nine SARS-CoV-2 Strains Detected from COVID-19 Patients in Bangladesh.
SARS_CoV_2 mutation literature information.
PMID: 
2021
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